J Nutr Health.  2014 Apr;47(2):99-105. 10.4163/jnh.2014.47.2.99.

Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats

Affiliations
  • 1R&D Center, TS Corporation, 116 Wolmi-ro, Jung-gu, Incheon 400-201, Korea.
  • 2Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea. yuri.kim@ewha.ac.kr
  • 3TS Food & System, Nonhyeon-ro 422-gil, Gangnam-gu, Seoul 135-921, Korea.

Abstract

PURPOSE
This study was conducted in order to investigate the diuretic effects of Erythritol (ET) salt on urinary electrolyte excretion in Sprague-Dawley Rats.
METHODS
Animals were divided into two groups: Salt group (n = 7) and Salt + ET fed group (n = 7). Animals were provided food and water ad libitum. Supplements were administered orally to animals for one week.
RESULTS
Body weights were not statistically different between groups either on Day 1 or Day 7. However, water consumption of the Salt + ET group was significantly higher than that of the Salt group on Day 1 and Day 7. Urine volume of the Salt + ET group was approximately 27% and 38% higher than that of the Salt group on Day 1 and Day 7. In addition, we found that the total amounts of urinary electrolytes, such as sodium and potassium, of the Salt + ET group were significantly higher than those of the Salt group on Day 7. We also found that serum electrolyte concentrations did not differ between two groups. These results demonstrated that salt intake with ET was effective in increasing urinary electrolyte excretion, which might be caused by higher water intake and diuretic effect inhibiting reabsorption of water, sodium, and potassium in renal tubules.
CONCLUSION
The results suggest that short-term supplementation of ET salt can be a potential diuretic agent by inhibiting sodium and potassium reabsorption and inducing loss of water.

Keyword

erythritol; salt; electrolyte excretion; diuretic effect; hypertension

MeSH Terms

Animals
Body Weight
Diuretics
Drinking
Electrolytes
Erythritol
Hypertension
Potassium
Rats*
Rats, Sprague-Dawley
Sodium
Water
Diuretics
Electrolytes
Erythritol
Potassium
Sodium
Water

Figure

  • Fig. 1 Effects of the Erythritol-Salt on serum concentration of sodium and potassium. A: The serum concentrtion of sodium in two groups was measured at Day 7. B: The serum concentration of potassium in two groups was measured at Day 7. Values are expressed as mean ± SD (n = 7). *: significantly different from Salt group value (p < 0.05).


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