J Nutr Health.  2014 Apr;47(2):89-98. 10.4163/jnh.2014.47.2.89.

Effects of calcium and vitamin D intake level on lipid metabolism in growing rats

• Lee SM
• Lee YJ
• Won ES
• Lee SS

• KMID: 2210022
• DOI: http://doi.org/10.4163/jnh.2014.47.2.89

Abstract

PURPOSE
Association of low intake of calcium (Ca) and inadequate vitamin D (VD) status with higher prevalence rates of obesity has been reported. This study was conducted in order to investigate the effects of different levels of whey Ca and VD intake on lipid metabolism in growing rats.
METHODS
A total of 56 five-week-old male Sprague-Dawley rats were divided into seven groups and fed for five weeks. Ca groups were divided into three levels, low, normal, and high (0.25%, 0.5%, 1%). VD subgroups in the low and high Ca groups were divided into three levels, low, normal, and high (10 IU, 1,000 IU, and 5,000 IU). The effects of Ca and VD on each group were evaluated by two way ANOVA.
RESULTS
Significantly higher amounts of abdominal fat, visceral fat, and epididymal fat were observed in the Low-Ca groups than in the Normal-Ca and High-Ca groups. Serum leptin levels of Low-Ca groups were higher than those of Normal-Ca and High-Ca groups. The highest serum parathyroid hormone concentration was observed in the low Ca.low VD group. The levels of serum 25(OH)D were significantly increased with increasing dietary VD levels. Significantly higher serum levels of triglycerides, total cholesterol, and HDL-cholesterol were observed in the low Ca groups than in the normal Ca and high Ca groups.
CONCLUSION
These results indicate that low calcium intake increased serum lipid level and body fat amount.

Keyword

calcium; vitamin D; 25(OH)D; serum lipid profile; fat mass

MeSH Terms

Abdominal Fat
Adipose Tissue
Animals
Calcium*
Cholesterol
Humans
Intra-Abdominal Fat
Leptin
Lipid Metabolism*
Male
Obesity
Parathyroid Hormone
Prevalence
Rats*
Rats, Sprague-Dawley
Triglycerides
Vitamin D*
Calcium
Cholesterol
Leptin
Parathyroid Hormone
Triglycerides
Vitamin D

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