J Korean Surg Soc.  2002 Apr;62(4):319-326.

The Expression of CD44s, CD44v5, CD44v6, p27(kip1) in Colorectal Carcinoma

• Jung IC
• Kim KH
• Park YJ
• Song BJ
• Lee MS
• Kim CN
• Chang SH
• Won JM
• Kim JI

Abstract

PURPOSE: In treating colorectal carcinoma, metastasis and recurrence are the most important problems encountering after a curative resection of the tumor. Therefore, understanding the mechanism of the disease progression and being able to predict the likelihood of recurrence is very important.
METHODS
In this study, 56 colorectal carcinoma cases were reviewed. Immunohistochemical staining on CD44s, CD44v5, CD44v6, and p27(kip1) were performed to determine the expression level of the protein, the patient's clinical findings and the pathophysiology.
RESULTS
1) CD44v5 showed a positive response in 47 (83.9%) out of 56 cases. By analyzing the Astler-Coller classification and the invasion of the lymphatic system, the value expressed was significantly high. 2) p27(kip1) showed a positive response in 35 (62.5%) out of 56 cases. As the disease progressed, there was a significant decrease according to analysis of Astler-Coller classification, and the invasion of the lymph node and lymphatics. The relationship showed an inverse correlation as the disease progressed. 3) For the CD44s and CD44v6, analysis by the Astler-Coller classification, the histological pattern, lymph node metastasis, invasion of the lymphatic system and the depth of the invasion, were not significantly different.
CONCLUSION
CD44v5 and p27(kip1) have a relationship with tumor progression, and is a valuable marker for prognosis. In particular, CD44v5 appeared to be involved in tumor progression where the tumor cells invaded the lymphatic system.

Keyword

Colorectal carcinoma; CD44; p27(kip1)

MeSH Terms

Classification
Colorectal Neoplasms*
Disease Progression
Lymph Nodes
Lymphatic System
Neoplasm Metastasis
Prognosis
Recurrence