J Korean Surg Soc.  2001 Jun;60(6):649-655.

The Clinical Value of p53, c-erbB-2 and Ki-67 Expression in Gallbladder Carcinoma

• Kim KH
• Choi SH
• Ahn CH
• Kim JS
• Jeon HM
• Lee EJ
• Lim KW

Abstract

PURPOSE: We evaluated the correlation between clinicopathologic features and p53, c-erbB-2 and Ki-67 protein expression in gallbladder carcinoma.
METHODS
From Jan. 1994 to July 1999, thirty-four cases of gallbladder carcinoma were enrolled in this study and their clinicopathologic findings were analyzed. We performed p53, c-erbB-2, and Ki-67 immunohistochemical staining on formalin fixed, paraffin embedded histological sections with an antibody.
RESULTS
The rate of overexpression of p53, c-erbB-2, and Ki-67 protein in gallbladder carcinoma was 47.1%, and 70.6%, 55.9%, respectively. The five year patient survival rate was significantly correlated only with tumor stage; the rate being 64.7% (P=0.031) with p53-negative tumors and 59.0% (P=0.023) with c-erbB-2-positive tumors.
CONCLUSION
Progressively increasing incidence of p53, c-erbB-2 and Ki-67 protein overexpression was observed in gallbladder carcinoma patients. Although this study found no correlation between the molecular markers and survival, further study will be needed to evaluate the significance of p53, c-erbB-2 and Ki-67 proteins as prognostic factors.

Keyword

Gallbladder cancer; p53; c-erbB-2; Ki-67; Immunohistochemical staining

MeSH Terms

Formaldehyde
Gallbladder Neoplasms
Gallbladder*
Humans
Incidence
Paraffin
Survival Rate
Formaldehyde
Paraffin