J Korean Surg Soc.
2000 Jun;58(6):867-871.
Pancreas-Intestinal Transplantation in Familial Adenomatous Polyposis Patients
- Affiliations
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- 1Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center.
Abstract
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Familial adenomatous poliposis is autosomal, predominantly inherited, premalignant disease, which is
caused by a mutation in adenomatous poliposis coli gene in chromosome 5q21. Intestinal transplantation
is an evolving procedure and has become a lifesaving procedure for pediatrics and adults with intestinal
failure who cannot be managed by conventional therapies. Long-term outcome and cost effectiveness
continue to improve and will be comparable to those of total parenteral nutrition. The short gut syndrome
is the most common indication. Pancreas transplantation, as a solid organ, vascularized graft, has im
proved the quality of life for diabetic patients by establishing an insulin-independent, constant normo
glycemic state and is a well-established treatment for patients with insulin-dependent diabetes. The bene
ficial effect is the maintenance of normoglycemia and possibly the reversal of diabetic complications,
such as vasculopathy, neuropathy, and nephropathy. We report a case of pancreas-intestinal transplantation
in a familial adenomatous polyposis patient along with a review of the literature.