J Korean Radiol Soc.  2004 Oct;51(4):433-439. 10.3348/jkrs.2004.51.4.433.

Endovenous Radiofrequency Ablation using Stent-type Electrode for Varicose Veins: an Experimental Study in Goats

• Won JH
• Kwak YL
• Han JH
• Oh CK
• Park SI

• KMID: 2209200
• DOI: http://doi.org/10.3348/jkrs.2004.51.4.433

Abstract

PURPOSE
The purpose of this study was to investigate the feasibility and the optimal conditions of radiofrequency (RF) ablation by using the stent-type electrode upon the saphenous vein of goats for the endovenous treatment of varicose veins.
MATERIALS AND METHODS
A self-expandable nitinol stent electrode (6 mm diameter, 2 cm length, cell size; 1.3x2 mm) was designed to expose the distal 1cm segment to allow for contact with the venous wall. The proximal part of the electrode was connected to the RF generator by insulated copper wires located within the stent electode introducer. Initially, to optimize the power setting, ablation of 6 saphenous veins in 3 goats was performed with power settings of 10, 20 and 30 W. Pull back rate of the electrode was 2 and 4 cm/min for each power level, respectively. The goats were sacrificed 4-6 weeks later and histologic examinations of the saphenous veins were done. For the second part of the experiment, RF ablation of 4 saphenous veins from 2 goats was done by applying the optimal power, based upon the first examination; these procedure was performed with variable pull back rates. Again, the goats were sacrificed 1-6 weeks later and histologic examinations were done.
RESULTS
Endovenous ablation of the goat saphenous veins at 20 W caused complete obliteration without complication. There was incomplete occlusion at 10 W, and there were vessel perforation, extravasation, and adjacent tissue injury at 30 W. In second part of the study, the complete circumferential obliteration of the vein was demonstrated at a pull back rate of 1 cm/min and 3 cm/min with the power of 20 W.
CONCLUSION
The stent-type electrode may be useful in endovenous RF ablation for treatment of varicose veins. For stents with a diameter of 6 mm, the optional combination of 20 W of power with a pull back rate of 1-3 cm/min produced the most favorable results. Further study and clinical investigations are warranted.

Keyword

Radiofrequency (RF) ablation; Varicose; Veins

MeSH Terms

Catheter Ablation*
Cell Size
Copper
Electrodes*
Goats*
Saphenous Vein
Stents
Varicose Veins*
Veins
Copper