J Korean Radiol Soc.
2004 Oct;51(4):381-387. 10.3348/jkrs.2004.51.4.381.
Glue Embolization of Aneurysm after Stenting in Canine Carotid Arteries - Technical Feasibility
- Affiliations
-
- 1Department of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, Korea.
- 2Department of Veterinary Toxicology, College of Veterinary Medicine, Kyungpook National University, Korea.
- 3Department of Pathololgy, Asan Medical Center, University of Ulsan, College of Medicine, Korea.
- 4Department of Radiology, Ewha Women's University, Korea.
- 5Department of Pediatric Cardiac Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Korea.
- KMID: 2209193
- DOI: http://doi.org/10.3348/jkrs.2004.51.4.381
Abstract
- PURPOSE
Coiling or infusion of embolic materials into a wide necked aneurysm can be performed with stenting. The purpose of our study is to assess the technical feasibility of aneurysm treatment with glue embolization after stenting.
MATERIALS AND METHODS
We used four Wallstents for surgically repairing eight canine carotid aneurysms. After confirmation of the aneurysms on the angiogram, we introduced a 6-7 F guiding catheter in order to deploy the stents. After stenting, we passed a microcatheter into the aneurysm lumen through the stent mesh. 28% glue was slowly injected until the glue cast completely filled the lumen. We evaluated the passage of a microcatheter through the stent meshwork, formation of the glue cast and the stents' ability to protection for any leakage of glue. The follow-up angiogram was obtained for two dogs, one to three times until 8 weeks, and then we sacrificed the dogs and performed pathologic examinations.
RESULTS
Stenting was successful in all cases except one in which the vessel was occluded because the stent was not completely expanded within the lumen. The microcatheter could not pass through the stent mesh in one aneurysm. The two week follow-up angiogram showed complete occlusion of the aneurysm and a patent carotid lumen in a case after successful stenting and glue embolization without distal migration of glue. Tungsten in the glue was noted to migrate out of aneurysm into the soft tissue of the neck. Histopathologic examination showed successful obliteration and stable organization of the aneurysmal lumen with ingrowth of fibroblasts and a foreign body reaction. In contrast, the aneurysms without the glue embolization being performed showed partially thrombosed aneurysmal lumens that became smaller and indistinct on the 8 week follow-up angiograms. Histopathologic examination showed a disorganized thrombus with numerous recanalizations.
CONCLUSION
Glue embolization after stenting could be performed for aneurysm without distal migration of the glue or gluing of the catheter. This concept appears to be useful for applications to the further research and the treatment of aneurysm.
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