J Korean Pediatr Soc.  1998 May;41(5):593-598.

A Clinical Study of Antithrombin lll Therapy for Disseminated Intravascular Coagulation in Neonates

• Kim JY
• Kim CN
• Chey MJ
• Cheong CY

Abstract

PURPOSE: The purpose of this study is to evaluate the clinical effect of antithrombin lll concentrates in disseminated intravascular coagulation (DIC) of neonates.
METHODS
We reviewed the clinical records of 11 newborn patients who had been admitted and diagnosed as DIC at the neonatal intensive care unit of Sanggye Paik Hospital from November, 1995 to September, 1996.
RESULTS
There were 6 males and 5 females. In 9 cases (81.8%), gestational age was less than 37 weeks and birth weight was less than 2,500g. Sepsis was the most common underlying disease in 9 cases (81.8%), followed by respiratory distress syndrome, necrotizing enterocolitis, and fulminant hepatitis. The etiologic organisms of sepsis, were gram negative organisms, fungus, and gram positive organisms in decreasing order. There were signs of gastrointestinal tract hemorrhage, pulmonary hemorrhage, and intracranial hemorrhage as a result of DIC. In the clinical outcome of DIC patients, 6 out of 11 patients survived (54.5%).
CONCLUSION
Administration of antithrombin lll concentrates in DIC of neonates produces improvement of clinical course and survival.

Keyword

Antithrombin lll; Disseminated intravascular coagulation

MeSH Terms

Birth Weight
Dacarbazine
Disseminated Intravascular Coagulation*
Enterocolitis, Necrotizing
Female
Fungi
Gastrointestinal Tract
Gestational Age
Hemorrhage
Hepatitis
Humans
Infant, Newborn*
Intensive Care, Neonatal
Intracranial Hemorrhages
Male
Sepsis
Dacarbazine