J Korean Ophthalmol Soc.
2005 Mar;46(3):554-559.
Two Cases of Klebsiella Pneumoniae Endogenous Endophthalmitis Treated with Sulperazone
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Hallym University, Chunchon, Korea. mcshin@hallym.ac.kr
Abstract
- PURPOSE
To report and review 2 cases of Klebsiella Pneumoniae endogenous endophthalmitis showing multi drug resistance that were treated with sulperazone. METHODS: Sulperazone was administered to two patients with Klebsiella Pneumoniae endogenous endophthalmitis: a 51-year-old male with orbital cellulitis who showed no response to vancomycin, ceftazidime, and amikacin for 6days; and a 67-year-old female who showed no response to cefotaxime, and amikacin. RESULTS: Proptosis and inflammation began to improve after changing to sulperazone. Therefore, enucleation and debridement could be avoided. CONCLUSIONS: Good results were obtained by use of Sulperazone which inactivates beta-lactamase irreversibly and which showed bactericidal effect to multi drug resistant Klebsiella Pneumoniae endogenous endophthalmitis.
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