J Korean Pediatr Soc.  2000 Aug;43(8):1106-1110.

Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus

• Hwang JS
• Yang SW

Abstract

PURPOSE: Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic beta-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic beta-cell function. The aim of this study was to determine factors influencing the onset of honeyrnoon period in children with type I DM.
METHODS
The study group was composed of 50 patients with type I DM. The honeymoon period was defined as a period requiring less than 0.5U/kg/day to maintain near-normal blood glucose control without urine glucose for consecutive days. The factors for three study were age at diagnosis, sex, initial 24-hr urine C-peptide, initial HbA C, diabetic ketoacidosis and maximum insulin dose for near-normal blood glucose control before honeymoon.
RESULTS
The group with honeymoon period received significantly smaller doses of insulin near-normal blood glucose control, compared to the group without honeymoon period, before honeymoon(P<0.01). Other factors had no significant connection with the development of honeymoon period.
CONCLUSION
The developrnent of honeymoon period in type I DM had a significant relationship with maximum insulin dose before the onset of honeymoon period for near-normal blood glucose control. This needs remains to be further study.

Keyword

Type 1 diabetes mellitus; Honeymoon period; Insulin

MeSH Terms

Autoimmune Diseases
Blood Glucose
C-Peptide
Child*
Diabetes Mellitus*
Diabetes Mellitus, Type 1
Diabetic Ketoacidosis
Diagnosis
Glucose
Humans
Insulin
Blood Glucose
C-Peptide
Glucose
Insulin