J Korean Ophthalmol Soc.  2003 Sep;44(9):2004-2009.

Laboratory Evaluation of Thrombophilic Factor in Retinal Vein Occlusive Disease

• Kim US
• Kim SW
• Yu SY
• Kwak HW

Abstract

PURPOSE
To evaluate the significance of thrombophilic factors in retinal vein occlusive diseases. METHODS: Thirty-two patients with retinal vein occlusion (19 patients at the age of 55 or less, 13 patients at the age of 56 or more) underwent laboratory evaluation for CBC, lipid profile, VDRL/TPHA, homocysteine, protein C activity, protein S activity, lipoprotein (a), platelet aggregation test, Factor V Leiden, lupus anticoagulant, anticardiolipin antibody, fibrinogen, and antithrombin III.
RESULTS
The abnormal laboratory findings (high homocysteine, hyperlipidemia, thrombocytosis, lipoprotein (a), high ESR, and decreased protein S activity) were found more often in patients of 55 years or less than those of 56 or more.
CONCLUSIONS
The thrombophilic factors were more common positive findings at or less than 55 years. Thrombophilic factor tests are recommended in young patients with retinal vein occlusion.

Keyword

Factor V Leiden; Homocysteine; Retinal vein occlusion; Thrombophilic factor; Young

MeSH Terms

Antibodies, Anticardiolipin
Antithrombin III
Factor V
Fibrinogen
Homocysteine
Humans
Hyperlipidemias
Lipoprotein(a)
Lupus Coagulation Inhibitor
Platelet Aggregation
Protein C
Protein S
Retinal Vein Occlusion
Retinal Vein*
Retinaldehyde*
Thrombocytosis
Antibodies, Anticardiolipin
Antithrombin III
Factor V
Fibrinogen
Homocysteine
Lipoprotein(a)
Lupus Coagulation Inhibitor
Protein C
Protein S
Retinaldehyde