J Korean Ophthalmol Soc.  2017 Mar;58(3):352-357. 10.3341/jkos.2017.58.3.352.

Central Retinal Vein Occlusion in Young Healthy Patients and the Role of Thrombophilia in Pathogenesis

• Lee YM
• Lee MW

• KMID: 2371919
• DOI: http://doi.org/10.3341/jkos.2017.58.3.352

Abstract

PURPOSE
We report two young patients who developed central retinal vein occlusion (CRVO) without any systemic disease, and various thrombophilia tests were performed to determine the etiology.
CASE SUMMARY
Two young patients, a 22-year-old female and a 23-year-old male, who had acute vision loss were diagnosed with nonischemic CRVO via fluorescein angiography. They had no other disease and no common risk factors for CRVO. We performed various tests to determine the thrombophilic risk factors and discovered a transient decrease in protein S antigen and protein C antigen in the female and male patients, respectively.
CONCLUSIONS
CRVO in young patients without systemic disorders may have different mechanisms in the pathology and thus additional laboratory tests to determine thrombophilic disorders are necessary.

Keyword

Central retinal vein occlusion; Protein C deficiency; Protein S deficiency; Thrombophilic disorder

MeSH Terms

Female
Fluorescein Angiography
Humans
Male
Pathology
Protein C
Protein C Deficiency
Protein S
Protein S Deficiency
Retinal Vein*
Risk Factors
Thrombophilia*
Young Adult
Protein C
Protein S