Clin Pediatr Hematol Oncol.  2011 Apr;18(1):54-57.

A Case of Central Retinal Vein Occlusion by Protein C Deficiency

Affiliations
  • 1Department of Pediatrics, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. isjeon@gilhospital.com

Abstract

Protein C (PC) is a vitamin K-dependent plasma protein synthesized as a zymogen by liver. It's active form has an anti-thrombotic activity by cleaving the coagulation factor Va and VIIIa. During the last few years, a large number of cases with protein C deficiency (PCD) which contain variable mutations have been documented. Those with hereditary protein C deficiency tend to have an increased risk of thromboembolism. Hypertension, diabetes, hyperlipidemia and glaucoma are the main underlying diseases of the retinal vein occlusion (RVO). Rarely, thrombophilia (antithrombin III, protein S, protein C deficiency) results in the RVO which usually occurs after adolescent period. We recently experienced a case of central retinal vein occlusion by a PCD.

Keyword

Protein C; Renal vein occlusion

MeSH Terms

Adolescent
Factor Va
Glaucoma
Humans
Hyperlipidemias
Hypertension
Liver
Plasma
Protein C
Protein C Deficiency
Protein S
Retinal Vein
Retinal Vein Occlusion
Thromboembolism
Thrombophilia
Vitamins
Factor Va
Protein C
Protein S
Vitamins
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