Mesenchymal Cell Tumors of the Gastrointestinal Tract

Shin, Keun Nam; Park, Young Kyu; Suh, Hae Hyeon; Kim, Young Bag; Kim, Dong Yee; Kim, Young Jin

Abstract

Mesenchymal cell tumors of the intestinal tract originate from connective tissues, muscles, fat, lymphatic tissues, blood vessels, and nerves in and beneath the submucosa. The most common site is the stomach, followed by the small bowel. Among the benign gastric neoplasms of mesodermal origin, those derived from smooth muscles constitute over 90%. Leiomyosarcomas of the stomach represent about 1% to 3% of primary malignant tumors and approximately 20% of submucosal tumors of the stomach. In the small bowel, leiomyoma is the most common benign tumor, and leiomyosarcoma represents about 19% of malignant tumors. The principle of surgical treatment of gastric mesenchymal tumors is local excision with a 2 to 3 cm margin in the surrounding gastric wall. We reviewed 48 cases of mesenchymal cell tumors of the gastrointestinal tract from January 1988 to March 1997 at the Department of Surgery, Namkwang General Hospital and Chonnam University Hospital School. The results are as follows : 1) There were 23 benign and 25 malignant tumors. 2) The most common benign tumor was leiomyoma (41.7%) and the most common malignant tumor was a leiomyosarcoma (47.9%). 3) The most common site was the stomach (52.1%), followed by the small bowel (25%); in the gastric tumor cases, the most common site was the body (60%). 4) The most common clinical manifestation was abdominal pain (37.5%), followed by bleeding (27.1%), a palpable mass, dyspepsia, and weight loss. 5) A wedge resection, a subtotal gastrectomy, or an enucleation of the mass was mainly performed on the stomach. Segmental resection and anastomosis was primarily performed in the small bowel. 6) Among the malignant tumors, a recurrence was noted in 8 patients(32%) : 7 leiomyosarcomas and 1 malignant histiocytoma. 7) The prognosis for a malignant leiomyosarcoma was better than that for an adenocarcinoma and was associated with tumor size and histologic grade (mitosis/10 HFP). However, we could not find any correlation between the prognosis and lymph node metastasis.