J Korean Ophthalmol Soc.  2000 Sep;41(9):1883-1890.

The Therapeutic Effects of Early Administration of 5%Na Cl Eye Drops on Corneal Edema Induced by Intracameral Injection of 2%Lidocaine in Rabbits

• Chun YS
• Kim JH
• Park IK
• Wee WR
• Lee JH

Abstract

The purpose of this study was to investigate the therapeutic effects of early administration of 5%NaCl on corneal edema induced by intracameral injection of 2%lidocaine. All thirty eyes of 30 rabbits were randomly assigned to one of the six study groups (group A and a, group B and b, group C and c). One of tenth ml of 2%lidocaine was injected intracamerally at right eyes of thirty rabbits. In group A, they were treated with 5% NaCl every 2 hours from 24 hours after the operation. In group B, from 12 hours and in group C, immediately after the operation. In control group a, b, c, they were treated with same method except balanced salt solution instead of 5%NaCl. Central corneal thickness (CCT)was measured before operation and after operation every 6 hours until the three successive records had no demonstrable changes compared to baseline levels. A statistically significant decrease of the CCT was found in group A compared with group a from 78 hours to 138 hours postoperatively. There was a statistically significant decrease of the CCT in the group B compared with that in group b from 42 hours after the operation. Recovery time to the preoperative levels was reduced by 66 hours. There was a statistically significant decrease of the CCT in the group C compared with that in group b from 18 hours after the operation. Recovery time to the preoperative levels was reduced by 84 hours. Early initiation of treatment with 5%NaCl following intracameral injection of 2%lidocaine reduced not only the amount of the corneal edema but also the recovery to the preoperative levels.

Keyword

Central corneal thickness; Corneal edema; 5%NaCl

MeSH Terms

Corneal Edema*
Ophthalmic Solutions*
Rabbits*
Ophthalmic Solutions