J Korean Soc Biol Psychiatry.
2003 Nov;10(2):126-132.
The Effects of Venlafaxine on Neurite Growth of PC12 Cells
- Affiliations
-
- 1Department of Neuropsychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul, Korea.
- 2Department of Neuropsychiatry, College of Medicine, Kwandong University, Myongji Hospital, Goyang, Korea.
- 3Department of Neuropsychiatry, College of Medicine, Hanyang University and Seoul National Hospital, Seoul, Korea.
- 4Department of Biochemistry and Molecular biology, College of Science, Hanyang University, Ansan, Korea.
Abstract
OBJECTIVES
The purpose of this study is to examine the effects of venlafaxine, one of novel antidepressant drugs, on neurite growth in PC12 cells.
METHODS
PC12 cells were cultured with NGF for eight days. Then different concentrations(0micrometer, 1micrometer, 5micrometer) of venlafaxine were mixed with cultured PC12 cells. After 24 hours and 48 hours of culture, we compared the effects of venlafaxine on the total length of neurites of cultured PC12 cells between no venlafaxine treated group(0micrometer) and venlafaxine treated groups(1micrometer and 5micrometer). Additionally, we studied the concentration-dependent effect of venlafaxine on differentiation in PC12 cells.
RESULTS
Experimental results showed that 1) the mean length of neurites in 1micrometer and 5micrometer venlafaxine treated group was more increased than no venlafaxine treated group(p=0.002). 2) the length of neurite in 5micrometer venlafaxine treated group was more elongated than 1micrometer venlafaxine treated group(p=0.046). 3) the length of neurite in 6micrometer venlafaxine treated group was more elongated than all the other concentrations in our experiment. Above 6micrometer, the length of neurite was shortened in inverse proportion to the concentration of venlafaxine.
CONCLUSIONS
This results suggest that venlafaxine, one of novel antidepressant drugs, promotes the differentiation of neuron. This study is believed to be a first step toward understanding the molecular and cellular mechanisms of antidepressant treatment.
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