J Korean Rheum Assoc.  2000 Jun;7(2):185-189.

Sulindac-induced Cholestatic Hepatitis and Acute Pancreatitis in a Patient having Systemic Sclerosis with Anti-RNP Antibody: report of a case

• Chang HK
• Kim YS
• Jeong H
• Park SO
• Kim SH
• Ko H
• Kang GH
• Kim JU

Abstract

Sulindac is a commonly used nonsteroidal anti-inflammatory drug (NSAID). It is relatively economical and seems to be less nephrotoxic due to its property of minimal renal prostaglandin inhibition. Although hepatic injury has been infrequently reported for nearly all NSAIDs currently on the market, sulindac has more commonly been associated with hepatotoxicity. In addition, it has been known that sulindac is the agent to have a definite association with pancreatitis. We describe a 37-year-old woman who developed cholestatic hepatitis and acute pancreatitis in association with sulindac. This patient met the diagnostic criteria of both mixed connective tissue disease and systemic sclerosis, in which the disease classification needs to be clarified. While being treated with sulindac, close observation and periodic liver function test seem to play an important role.

Keyword

Sulindac; Cholestatic hepatitis; Pancreatitis; Systemic sclerosis; Mixed connective tissue disease

MeSH Terms

Adult
Anti-Inflammatory Agents, Non-Steroidal
Classification
Female
Hepatitis*
Humans
Liver Function Tests
Mixed Connective Tissue Disease
Pancreatitis*
Scleroderma, Systemic*
Sulindac
Anti-Inflammatory Agents, Non-Steroidal
Sulindac