J Korean Rheum Assoc.
2006 Mar;13(1):56-63.
Diagnostic Availability of Ultrasonography and the Effects of Methotrexate Therapy in Patients with Eosinophilic Fasciitis: Report of Two Cases
- Affiliations
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- 1Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
- 2Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea.
- 3Department of Diagnostic Radiology, Chonbuk National University Medical School, Jeonju, Korea. syl@chonbuk.ac.kr
- 4Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Abstract
- Eosinophilic fasciitis (EF) is a rare disorder of unknown etiology characterized by eosinophilia, indurations of the skin, and inflammation of the fascia. Magnetic resonance imaging (MRI) has been used to assist the diagnosis and to monitor the response to treatment, and the commonly used therapy has been corticosteroids. However, the use of ultrasonography (US) in the diagnosis and the management of EF has not been reported previously in Korea. In addition, the effects of methotrexate (MTX) treatment have rarely been reported in corticosteroid-resistant patients with EF. Here, we describe two cases of EF resistant to corticosteroid therapy alone where the combination of MTX and corticosteroids was effective. Furthermore, we show that US is useful modality in supporting the clinical diagnosis and monitoring the response to treatment of patients with EF.
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