J Korean Soc Menopause.  2011 Aug;17(2):75-80.

Serum Concentration of Estradiol and Estrone Following Oral Administration of Low-dose Hormone Therapy in Postmenopausal Korean Women

Affiliations
  • 1Department of Obstetrics and Gynecology, Chung-Ang University School of Medicine, Seoul, Korea. hmpark@hanafos.com
  • 2Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, Seoul, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 5Department of Obstetrics and Gynecology, Busan, Inje University College of Medicine, Seoul, Korea.
  • 6Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
To determine the baseline serum concentrations of estradiol and estrone in postmenopausal Korean women and the serum concentrations of estradiol and estrone after 4 and 16 weeks of treatment using 1 mg of estradiol and 2 mg of drospirenone.
METHODS
This was a multicenter study. Thirty-six subjects were screened. Serum estradiol, estrone and drospirenone levels were determined by gas chromatography-mass spectrometry and radioimmunoassay.
RESULTS
The mean estradiol concentration was 8.37 +/- 12.1 pg/mL at baseline and increased to 53.7 +/- 52.1 and 41.4 +/- 26.1 pg/mL after 4 and 16 weeks of treatment, respectively. The mean estrone concentrations were 28.7 +/- 26.8, 266.1 +/- 182.9, and 256.1 +/- 179.1 pg/mL at baseline, and after 4 and 16 weeks of treatment, respectively. When women were stratified according to the basal estradiol level, the level after 4 weeks of treatment was significantly higher in the women with a detectable level (> or = 5 pg/mL) than in women with an undetectable level (< 5 pg/mL; 65.2 +/- 21.5 vs. 37.4 +/- 25.8 pg/mL, P = 0.008). After 16 weeks of treatment, the estradiol level was still higher in the detectable group (51.6 +/- 28.6 vs. 38.7 +/- 21.7 pg/mL, P = 0.09).
CONCLUSION
This study showed that 1 mg of estradiol and 2 mg of drospirenone is an appropriate regimen to achieve the desired serum estradiol level. The difference in serum hormonal levels after 4 weeks of treatment could be caused by different basal levels.

Keyword

Drospirenone; Estradiol; Estrogen replacement therapy; Estrone; Postmenopause

MeSH Terms

Administration, Oral
Androstenes
Estradiol
Estrogen Replacement Therapy
Estrone
Female
Gas Chromatography-Mass Spectrometry
Humans
Postmenopause
Androstenes
Estradiol
Estrone
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