J Korean Radiol Soc.  1999 Mar;40(3):481-486. 10.3348/jkrs.1999.40.3.481.

The Effect of Subsegmental Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma: PathologicCorrelation

• Pyeun YS
• Do YS
• Choo SW
• Park HS
• Lee WJ
• Koh KC
• Paik SW
• Joh JW
• Kim YI
• Choo IW

• KMID: 2201035
• DOI: http://doi.org/10.3348/jkrs.1999.40.3.481

Abstract

PURPOSE: To assess the effectiveness of subsegmental transcatheter arterial chemoembolization(TAE) forhepatocellular carcinomas(HCCs) on the basis of tumor necrosis rate. MATERIAL AND METHODS: Between May 1996 andMarch 1998, ten patients with single HCC after subsegmental TAE underwent surgical resection. Subsegmental TAE wasperformed by injecting a mixture of lipiodol and adriamycin followed by gelatin sponge particles into the distalbranches of the subsegmental arteries. Tumor size and the extent of necrosis were analyzed in ten resectedlesions, and in all patients, complications after subsegmental TAE were assessed. RESULTS: The size of resectedtumors ranged from 1 to 5,5cm. On histological examination, complete necrosis was seen in 6 to 10 resected lesionsand 95% necrosis in three. In the remaining lesion, 85% necrosis had occured. Complete necrosis was noted in 4 of6 small HCCs(less than 3cm in diameter), while in the remaining two the extent of necrosis was 95%. Nocomplications were observed.
CONCLUSION
For the treatment of HCC, subsegmental TAE is safe and effective.Curative therapy must, however, involve follow-up and repeated TAE.

Keyword

Liver neoplasms, chemotherapeutic infusion; Liver neoplasms; CT; Liver neoplasms, angiography

MeSH Terms

Arteries
Carcinoma, Hepatocellular*
Doxorubicin
Ethiodized Oil
Follow-Up Studies
Gelatin
Humans
Liver Neoplasms
Necrosis
Porifera
Doxorubicin
Ethiodized Oil
Gelatin