J Menopausal Med.  2015 Apr;21(1):36-40. 10.6118/jmm.2015.21.1.36.

Evaluation of Bone Density Measurement in Type 2 Diabetic Postmenopausal Women with Hypertension and Hyperlipidemia

• Caglayan E
• Engin-Ustun Y
• Sari N
• Karacavus
• Seckin L
• Kara M

• KMID: 2201020
• DOI: http://doi.org/10.6118/jmm.2015.21.1.36

Abstract

OBJECTIVES
The aim of the study was to compare bone mineral density (BMD) in healthy postmenopausal women to BMD in type 2 diabetic hypertensive postmenopausal women with hyperlipidemia.
METHODS
Fifty type 2 diabetic and hypertensive postmenopausal women with hyperlipidemia and 51 age and body mass index (BMI) matched healthy postmenopausal women were included. Lumbar spine and femoral neck BMD were noted in both groups. BMD was measured using dual energy X-ray absorptiometry (DXA). Serum alkaline phosphatase (ALP), calcium and phosphorous were also measured. Pearson correlation coefficients were used to establish the relationship between various clinical characteristics.
RESULTS
There were no significant differences between two groups in respect to lumbar and vertebral BMD values, age, BMI, gravidity, parity. Serum cholesterol and fasting glucose levels were significantly different between each groups (P = 0.0001, P = 0.002).
CONCLUSION
We found that, accompanying chronic diseases such as diabetes, hypertension and hyperlipidemia don't affect the BMD measurements at postmenopausal period. So these postmenopausal women don't have excess risk regarding osteoporosis.

Keyword

Bone density; Hyperlipidemias; Postmenopause

MeSH Terms

Absorptiometry, Photon
Alkaline Phosphatase
Body Mass Index
Bone Density*
Calcium
Cholesterol
Chronic Disease
Fasting
Female
Femur Neck
Glucose
Gravidity
Humans
Hyperlipidemias*
Hypertension*
Osteoporosis
Parity
Postmenopause
Spine
Alkaline Phosphatase
Calcium
Cholesterol
Glucose

Reference

1. Tuominen JT, Impivaara O, Puukka P, Rönnemaa T. Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care. 1999; 22:1196–1200.

2. Compston JE, Smith EM, Matthews C, Schofield P. Whole body composition and regional bone mass in women with insulin-dependent diabetes mellitus. Clin Endocrinol (Oxf). 1994; 41:289–293.

3. Nicodemus KK, Folsom AR. Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care. 2001; 24:1192–1197.

4. Avery L. Diabetes mellitus types 1 and 2: an voerview. Nurs Stand. 1998; 13:35–38.

5. Sosa M, Dominguez M, Navarro MC, Segarra MC, Hernández D, de Pablos P, et al. Bone mineral metabolism is normal in non-insulin-dependent diabetes mellitus. J Diabetes Complications. 1996; 10:201–205.

6. Johnston CC Jr., Hui SL, Longcope C. Bone mass and sex steroid concentrations in postmenopausal Caucasian diabetics. Metabolism. 1985; 34:544–550.

7. van Daele PL, Stolk RP, Burger H, Algra D, Grobbee DE, Hofman A, et al. Bone density in non-insulin-dependent diabetes mellitus. The Rotterdam Study. Ann Intern Med. 1995; 122:409–414.

8. Stolk RP, Van Daele PL, Pols HA, Burger H, Hofman A, Birkenhager JC, et al. Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study. Bone. 1996; 18:545–549.

9. Gerdhem P, Isaksson A, Akesson K, Obrant KJ. Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus. Osteoporos Int. 2005; 16:1506–1512.

10. Son GH, Kim JH, Kwon JY, Kim YH, Park YW. Risk factors for cesarean delivery after induction of labor in nulliparous women with an unfavorable cervix at or beyond 41 weeks of gestation. Gynecol Obstet Invest. 2013; 76:254–259.

11. Carnevale V, Romagnoli E, D'Erasmo L, D'Erasmo E. Bone damage in type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2014; 24:1151–1157.

12. Kanazawa I, Yamaguchi T, Sugimoto T. Relationship between bone biochemical markers versus glucose/lipid metabolism and atherosclerosis; a longitudinal study in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2011; 92:393–399.

13. Viegas M, Costa C, Lopes A, Griz L, Medeiro MA, Bandeira F. Prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus and their relationship with duration of the disease and chronic complications. J Diabetes Complications. 2011; 25:216–221.

14. Anaforoglu I, Nar-Demirer A, Bascil-Tutuncu N, Ertorer ME. Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes. J Diabetes Complications. 2009; 23:12–17.

15. Kao WH, Kammerer CM, Schneider JL, Bauer RL, Mitchell BD. Type 2 diabetes is associated with increased bone mineral density in Mexican-American women. Arch Med Res. 2003; 34:399–406.

16. Sarkis KS, Pinheiro Mde M, Szejnfeld VL, Martini LA. High bone density and bone health. Endocrinol Nutr. 2012; 59:207–214.

17. Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol. 2000; 20:2346–2348.

18. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, et al. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res. 1999; 14:2067–2078.

19. Poli A, Bruschi F, Cesana B, Rossi M, Paoletti R, Crosignani PG. Plasma low-density lipoprotein cholesterol and bone mass densitometry in postmenopausal women. Obstet Gynecol. 2003; 102:922–926.

20. Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS, et al. Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int. 2005; 16:1975–1981.

21. Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone. 2009; 44:208–213.

22. Demir B, Haberal A, Geyik P, Baskan B, Ozturkoglu E, Karacay O, et al. Identification of the risk factors for osteoporosis among postmenopausal women. Maturitas. 2008; 60:253–256.

23. Begic Z, Balic D, Rizvanovic M. The association between lipid profile and bone density in postmenopausal women. Med Arch. 2012; 66:378–381.

24. Lupattelli G, Scarponi AM, Vaudo G, Siepi D, Roscini AR, Gemelli F, et al. Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women. Metabolism. 2004; 53:744–748.

25. Montagnani A, Gonnelli S, Cepollaro C, Pacini S, Campagna MS, Franci MB, et al. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study. Bone. 2003; 32:427–433.

26. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY. Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone. 2007; 40:1581–1587.

27. Olmos JM, Hernández JL, Martínez J, Castillo J, Valero C, Pérez Pajares I, et al. Bone turnover markers and bone mineral density in hypertensive postmenopausal women on treatment. Maturitas. 2010; 65:396–402.

28. Shen C, Deng J, Zhou R, Chen J, Fan S, Li Z, et al. Relation between bone mineral density, bone loss and the risk of cardiovascular disease in a Chinese cohort. Am J Cardiol. 2012; 110:1138–1142.

29. Javed F, Khan SA, Ayers EW, Aziz EF, Akram MS, Nadkarni GN, et al. Association of hypertension and bone mineral density in an elderly African American female population. J Natl Med Assoc. 2012; 104:172–178.