J Lab Med Qual Assur.
2013 Dec;35(2):133-137.
Artifactual Hyperbilirubinemia due to Paraprotein Interference in a Case of Multiple Myeloma
- Affiliations
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- 1Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. u931018@yonsei.ac.kr
- 2Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Abstract
- When analyzing samples containing paraproteins, various interference effects are encountered in the clinical laboratory. Precipitation of paraproteins mostly interferes with the assays that use photometric detection. Herein, we present a case of a patient with multiple myeloma who had paraproteins and spuriously elevated total bilirubin levels (31.1 mg/dL), which were measured by using Roche total bilirubin assay on the Modular DPE (Roche Diagnostics, Switzerland) chemical analyzer. The total bilirubin concentration reduced from 31.1 mg/dL to 1.5 mg/dL, when tested after three fold dilution of the sample on Modular DPE chemical analyzer.
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