J Lung Cancer.  2010 Dec;9(2):91-96. 10.6058/jlc.2010.9.2.91.

Pulmonary Metastasectomy for Colorectal Carcinoma

• Choi KH
• Lee YH
• Park KT
• Han IY
• Yoon YC
• Cho KH

• KMID: 2199913
• DOI: http://doi.org/10.6058/jlc.2010.9.2.91

Abstract

PURPOSE
Surgical resection is an important curative treatment for pulmonary metastases from colorectal adenocarcinoma. We analyzed the outcomes and the prognostic factors related to the post operative mortality after surgical resection for pulmonary metastases from colorectal adenocarcinoma.
MATERIALS AND METHODS
Between January 1994 and December 2009, 28 patients underwent complete pulmonary resection of metastatic colorectal carcinoma. We performed a retrospective review of the patient's characteristics and the factors affecting survival. Survival was analyzed by the Kaplan-Meier method and comparison between groups was performed by a log-rank analysis.
RESULTS
The median survival was 53.07 months (Kaplan-Meier method). The number of pulmonary metastases (p=0.0151) and a prethoracotomy carcinoembryonic antigen (CEA) level over 5 ng/mL (p=0.0217) were significantly related with survival.
CONCLUSION
The prethoracotomy CEA level and the number of metastases were significantly related with the survival rate. Resection of pulmonary metastatic lung lesion from colorectal cancer may improve the survival rate in a selected group of patients.

Keyword

Neoplasm metastasis; Colorectal neoplasm; Thoracic surgery

MeSH Terms

Adenocarcinoma
Carcinoembryonic Antigen
Colorectal Neoplasms
Humans
Lung
Metastasectomy
Neoplasm Metastasis
Retrospective Studies
Survival Rate
Thoracic Surgery
Carcinoembryonic Antigen

Figure

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  Fig. 1. Overall survival after curative pulmonary resection (n=28).

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  Fig. 2. Survival of patients with elevated prethoracotomy carcinoembryonic antigen (CEA) vs. patients with normal prethoracotomy CEA (n=28, p=0.0217).

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  Fig. 3. Survival of patients with number of pulmonary metastases (n=28, p=0.0151).

Reference

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