J Lung Cancer.  2012 Dec;11(2):94-96. 10.6058/jlc.2012.11.2.94.

Mixed Squamous Cell and Glandular Papilloma Presented with Peripheral Lung Mass: A Case Report

  • 1Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. Hanjho@skku.edu
  • 2Department of Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Thoracic Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea.


Mixed squamous cell and glandular papilloma is a rare pulmonary neoplasm typically occurring in the central lung area. Herein, we report a case of peripherally located mixed papilloma in a 54-year-old man with a complaint of dyspnea. Chest computed tomography demonstrated an infiltrative peripheral lung mass in the right middle lobe, measuring 1.5 cm in diameter. The resected lung tumor had papillary configuration lined by both squamous cell epithelium and mucin-containing glandular epithelium. The papillary stroma showed a fibrovascular core with inflammatory infiltrates. p63 immunostaining was positive in basal and parabasal tumor cells in papillary fronds.


Lung; Neoplasms; Papilloma

MeSH Terms

Lung Neoplasms


  • Fig. 1 (A) Chest computed tomography shows a peripheral lung mass with spiculated margin (arrows). (B, C) Low magnification view exhibits a papillary pattern filled with bronchiolar and alveolar spaces (H&E, ×10). (D, E) On high power view, the papillary structures are lined by both components of squamous and glandular epithelial cells. The papillary stalk has central fibrovascular cores with inflammatory infiltration (H&E, ×100). (F) Staining for p63 shows immunoreactivity in basal and parabasal cells in papillary fronds (ABC, ×200).


1. Inamura K, Kumasaka T, Furuta R, et al. Mixed squamous cell and glandular papilloma of the lung: a case study and literature review. Pathol Int. 2011. 61:252–258.
2. Tryfon S, Dramba V, Zoglopitis F, et al. Solitary papillomas of the lower airways: epidemiological, clinical, and therapeutic data during a 22-year period and review of the literature. J Thorac Oncol. 2012. 7:643–648.
3. Jackson C, Jackson CL. Benign tumors of the trachea and bronchi with especial reference to tumor-like formations of inflammatory origin. JAMA. 1932. 99:1747–1754.
4. Sung CO, Kim J, Do IG, Han J. Solitary pulmonary mixed squamous cell and glandular papilloma: a brief case report. Korean J Pathol. 2008. 42:393–395.
5. Abiko T, Koizumi S, Takanami I, Tanaka F. 18F-FDG-PET/CT findings in primary pulmonary mixed squamous cell and glandular papilloma. Ann Nucl Med. 2011. 25:227–229.
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