J Lung Cancer.  2012 Dec;11(2):66-70. 10.6058/jlc.2012.11.2.66.

Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and the Survival of Non-Small Cell Lung Cancer

• Hong MJ
• Choi YY
• Do SK
• Jeon HS
• Yoo SS
• Lee WK
• Lee SY
• Lee J
• Cha SI
• Kim CH
• Lee E
• Park JY

• KMID: 2199831
• DOI: http://doi.org/10.6058/jlc.2012.11.2.66

Abstract

PURPOSE
Nowadays, chromosomal regions containing genes associated with the risk of lung cancer are identified by a number of genome-wide association studies (GWASs). As part of the study, GWAS has identified the association of six chromosomal regions, 1q23, 4q22, 4q31, 5p15, 6p21, and 15q25, as being associated with lung cancer risk in the European population. We investigated the impact of genetic variants identified in GWASs for lung cancer susceptibility on the survival outcomes in patients with early stage non-small cell lung cancer (NSCLC).
MATERIALS AND METHODS
Three hundred and sixty-three patients with surgically resected NSCLC were enrolled. Eight single nucleotide polymorphisms (SNPs), rs2808630 on 1q23, rs7671167 on 4q22, rs1489759 and rs2202507 on 4q31, rs2736100 and rs402710 on 5p15, rs1052486 on 6p21 and rs16969968 on 15q25, were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay. The associations between genotypes and overall survival (OS) and disease-free survival (DFS) were analyzed.
RESULTS
None of the eight SNPs were significantly associated with OS or DFS. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and the survival outcomes.
CONCLUSION
These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility may not affect the prognosis of early stage NSCLC.

Keyword

Non-small cell lung carcinoma; Survival; Disease susceptibility

MeSH Terms

Carcinoma, Non-Small-Cell Lung
Disease Susceptibility
Disease-Free Survival
Genome-Wide Association Study
Genotype
Humans
Lung
Lung Neoplasms
Polymorphism, Single Nucleotide
Prognosis
Smoke
Smoking
Smoke

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