J Korean Soc Endocrinol.
2001 Apr;16(2):238-244.
Three Cases of Autoimmune Thyroid Disease in a Family through Three Generation
- Affiliations
-
- 1Department of Internal Medicine, Hanil General Hospital, Seoul, Korea.
- 2Deparment of Nuclear Medicine, Hanil General Hospital, Seoul, Korea.
Abstract
- According to recent studies, the immunogenetic factors are thought to be account for a part of the etiopathogenesis of autoimmune thyroid disease. In Korea, there was one report on the relationship between HLA DR5, DR8, B13 and autoimmune thyroid disease. There were also several reports on a familial hereditary transmission of autoimmune thyroid disease in other countries but not in Korea. We describe the occurrence of autoimmune thyroid disease that affected three members of a family through three generations. This is the first report on familial hereditary transmission of autoimmune thyroid disease in Korea. We report on an 80-year-old woman who presented with Hashimoto's thyroiditis, her 53-year-old daughter who had Graves' disease, and her 29-year-old grand-daughter who had Graves' disease. In order to identify the immunogenetic influence in these cases, HLA haplotypes & thyroid autoantibody were studied. HLA DRB3*02 was obseved in each of the patents. HLA DQB1*0301, DR11, DQB1*05031 and DR14 were observed in the two cases. However, HLA B13, DR5 and DR8 were not observed. The patients are currently undergoing follow-up using PTU, methimazole and synthyroid medication.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Autoimmune Thyroiditis during Antiviral Therapy with Peginterferon
- Autoimmune Thyroid Diseases
- Cyclosporine Treatment in a Patient with Concurrent Autoimmune Urticaria and Autoimmune Hepatitis
- A Case Report of Hyperthyroidism and Hypothyroidism Converted Three Times in a Graves' Disease Patient
- Recent Advances in Autoimmune Thyroid Diseases
