J Korean Soc Transplant.  1997 May;11(1):41-48.

Assessment of sICAM-1 and sVCAM-1 in Patients with Chronic Renal Allograft Dysfunction

• Kim YS
• Kim HO
• Choi KH
• Jeong HJ
• Kim TK
• Kim SI
• Kim MS
• Moon JI
• Lee EM
• Park KI

Abstract

AIMS: To examine the relationship between soluble adhesion molecules ICAM-1 and VCAM-1, and chronic renal allograft dysfunction
METHODS
Serum samples taken on the day of renal biopsy from renal allograft recipients showing chronic graft dysfunction(n=31), at least one year after renal transplantation, were examined and compared with those from healthy control(n=20), or end stage renal failure patients(n=18), for the measurement of sICAM-1 and sVCAM-1. Specific enzyme-linked immunometric method were used. No pateints was experiencing concurrent infection. The indications of the biopsy were slow increment of serum creatinine, significant proteinuria(over 1 gram per day) or newly-developed microscopic hematuria with or without small amount of proteinuria.
RESULTS
sVCAM-1 was increased in end stage renal failure patients as well as transplant recipients as compared with the healthy controls. However, sICAM-1 was not increased either in end stage renal failure patients or renal allograft recipients. The degree of chronic rejection and cyclosporine toxicity did not correlate with the serum level of sVCAM-1. The level of serum creatinine did not correlate with the serum levels of either sICAM-1 or sVCAM-1.
CONCLUSION
Increase of sVCAM-1 but not of sICAM-1 may have some role in the mechanism of chronic renal allograft dysfunction.

Keyword

Soluble adhesion molecule; Renal transplantation

MeSH Terms

Allografts*
Biopsy
Creatinine
Cyclosporine
Hematuria
Humans
Intercellular Adhesion Molecule-1
Kidney Transplantation
Proteinuria
Renal Insufficiency
Transplantation
Transplants
Vascular Cell Adhesion Molecule-1
Creatinine
Cyclosporine
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1