J Korean Soc Pediatr Endocrinol.  2001 Jun;6(1):77-84.

A Case of Severe Hypertension associated with Growth Hormone Therapy

• Heo N
• Oh CH
• Huh J
• Oh PS
• Lee HJ
• Yoon HS

Abstract

The use of recombinant DNA technology to produce human growth hormone has resulted in a marked increase in availability of Growth Hormone(GH) to treat short stature due to GH deficiency and other conditions, such as Turner syndrome, familial short stature, chronic renal insufficiency and intrauterine growth retardation (IUGR). But, the GH therapy may result in the adverse events such as sodium and water retention, pseudotumor cerebri, slipped capital femoral epiphysis, growth of nevi, recurrence of tumor. We experienced a case of severe hypertension associated with GH therapy in a 14-year-old male who presented high blood pressure up to 190/100 mmHg and normalized at 2-3 weeks after discontinuation of GH. Therefore, we think that the blood pressure should be carefully monitored during GH therapy.

Keyword

Growth hormone therapy; Hypertension; Blood pressure

MeSH Terms

Adolescent
Blood Pressure
DNA, Recombinant
Fetal Growth Retardation
Growth Hormone*
Human Growth Hormone
Humans
Hypertension*
Male
Nevus
Noonan Syndrome
Pseudotumor Cerebri
Recurrence
Renal Insufficiency, Chronic
Slipped Capital Femoral Epiphyses
Sodium
DNA, Recombinant
Growth Hormone
Human Growth Hormone
Sodium