J Korean Soc Pediatr Endocrinol.  2010 Dec;15(3):198-202.

Growth Hormone Treatment for Fanconi Anemia with Growth Hormone Deficiency

• Kim MK
• Kang MJ
• Chung HR
• Shin CH
• Yang SW

Abstract

Short stature is common in case of Fanconi anemia (FA) and may result from inherent abnormalities of FA or endocrinopathies, such as a growth hormone deficiency and hypothyroidism. Growth hormone treatment in FA patients with growth hormone deficiency (GHD) has been controversial because FA itself has a risk of malignancy, and there has been a concern about the increased risk of malignancy from growth hormone treatment. We report on an FA boy with GHD who was diagnosed with FA and undertook stem cell transplantation. Because he showed severe growth failure, growth hormone therapy was initiated at 6 years of age, after he was diagnosed with hypopituitarism, including GHD. He expressed significant catch-up growth with no complications beyond the two year follow up period. This case suggests that growth hormone therapy can be considered in patients with GHD caused by FA, with careful monitoring for malignancy.

Keyword

Fanconi anemia; Growth hormone deficiency

MeSH Terms

Fanconi Anemia
Follow-Up Studies
Growth Hormone
Humans
Hypopituitarism
Hypothyroidism
Stem Cell Transplantation
Growth Hormone