J Korean Neurotraumatol Soc.  2010 Jun;6(1):57-65. 10.13004/jknts.2010.6.1.57.

The Clinical Characteristics of Atraumatic Intracranial Abscess Patients

Affiliations
  • 1Department of Neurosurgery, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. nseykim@gilhospital.com
  • 2School of Medicine, Gachon University of Medicine and Science, Incheon, Korea.

Abstract


OBJECTIVE
The purpose of this study is to demonstrate clinical characteristics of atraumatic intracranial abscesses according to analyze the medical records and imaging studies of patients.
METHODS
This study is performed with retrospective reviews of medical records of 15 patients which were admitted under the diagnosis as atraumatic intracranial abscess from 2004 to 2009.
RESULTS
The infection entities were 2 epidural abscess, 1 subdural abscess, and 13 brain abscesses. Among them, 8 cases were bacterial infections, 6 unknown organisms, and 1 toxoplasmosis. 14 patients were managed with surgical and medical treatments. 1 patient was treated with medication only. Generally, the outcome was good and no mortality was recorded. According to the results of this study, the preponderance of smoking and alcoholics of intracranial abscesses were suggested.
CONCLUSION
To diagnose intracranial abscess accurately, more careful listening to the patient's history including smoking, alcohol consumption, and disease is necessarily required. The prognosis of the intracranial abscess would be good if accurate results for pathogens, appropriate usage of antibioticis, and suitable surgical method were done.

Keyword

Atraumatic; Intracranial abscess; Behavior; Medical history; Pathogen

MeSH Terms

Abscess
Alcohol Drinking
Alcoholics
Bacterial Infections
Brain Abscess
Epidural Abscess
Humans
Medical Records
Prognosis
Retrospective Studies
Smoke
Smoking
Toxoplasmosis
Smoke

Figure

  • FIGURE 1 Preoperative MRI findings. T2 weighted image (A) shows high signal intensity mass around low signal intensity rim and peripheral edema. Enhanced T1 weighted image (B) shows low signal intensity mass with well-enhanced rim.

  • FIGURE 2 Preoperative MRI shows the ill defined high signal intensity lesion on T2 weighted image (A) and multiple small enhanced masses on enhanced T1 weighted image (B).


Reference

1. Agarwal AK, Garg R, Simon M. Ring enhancing lesion on CT scan: metastases or a brain abscess? Emerg Med J. 2007; 24:706.
Article
2. Anslow P. Cranial bacterial infection. Eur Radiol. 2004; 14:Suppl 3. E145–E154.
Article
3. Bagaitkar J, Demuth DR, Scott DA. Tobacco use increases susceptibility to bacterial infection. Tob Induc Dis. 2008; 4:12.
Article
4. Barlas O, Sencer A, Erkan K, Eraksoy H, Sencer S, Bayindir C. Stereotactic surgery in the management of brain abscess. Surg Neurol. 1999; 52:404–410. discussion 411.
Article
5. Black P, Graybill JR, Charache P. Penetration of brain abscess by systemically administered antibiotics. J Neurosurg. 1973; 38:705–709.
Article
6. Black PM, Levine BW, Picard EH, Nirmel K. Asymmetrical hydrocephalus following ventriculitis from rupture of a thalamic abscess. Surg Neurol. 1983; 19:524–527.
7. Brewer NS, MacCarty CS, Wellman WE. Brain abscess: a review of recent experience. Ann Intern Med. 1975; 82:571–576.
Article
8. Cansever T, Izgi N, Civelek E, Aydoseli A, Kiris T, Sencer A. Retrospective analysis of changes in diagnosis, treatment and prognosis of brain abscess for a period of thirty-three-years. In : 13th World Congress of Neurological Surgery; June 19-24, 2005; Marrakesh. Nyon Vaud, Switzerland: World Federation of Neurosurgical Societies;2005. (Abstract).
9. Carpenter J, Stapleton S, Holliman R. Retrospective analysis of 49 cases of brain abscess and review of the literature. Eur J Clin Microbiol Infect Dis. 2007; 26:1–11.
Article
10. Chun CH, Johnson JD, Hofstetter M, Raff MJ. Brain abscess. A study of 45 consecutive cases. Medicine (Baltimore). 1986; 65:415–431.
11. Desprechins B, Stadnik T, Koerts G, Shabana W, Breucq C, Osteaux M. Use of diffusion-weighted MR imaging in differential diagnosis between intracerebral necrotic tumors and cerebral abscesses. AJNR Am J Neuroradiol. 1999; 20:1252–1257.
12. Erdoğan E, Cansever T. Pyogenic brain abscess. Neurosurg Focus. 2008; 24:E2.
Article
13. Everett ED, Strausbaugh LJ. Antimicrobial agents and the central nervous system. Neurosurgery. 1980; 6:691–714.
Article
14. Gillet GR, Garner JE, Bremner DA. Antimicrobial management of intracranial abscess. Aust N Z J Surg. 1984; 54:253–255.
Article
15. Goodkin HP, Harper MB, Pomeroy SL. Intracerebral abscess in children: historical trends at Children's Hospital Boston. Pediatrics. 2004; 113:1765–1770.
Article
16. Gordts F, Clement PA, Destryker A, Desprechins B, Kaufman L. Prevalence of sinusitis signs on MRI in a non-ENT pediatric population. Rhinology. 1997; 35:154–157.
17. Gortvai P, De Louvois J, Hurley R. The bacteriology and chemotherapy of acute pyogenic brain abscess. Br J Neurosurg. 1987; 1:189–203.
Article
18. Greenberg MS. Handbook of Neurosurgery. ed 5. New York: Thieme;2001. p. 217–223.
19. Guzman R, Barth A, Lövblad KO, El-Koussy M, Weis J, Schroth G, et al. Use of diffusion-weighted magnetic resonance imaging in differentiating purulent brain processes from cystic brain tumors. J Neurosurg. 2002; 97:1101–1107.
Article
20. Haimes AB, Zimmerman RD, Morgello S, Weingarten K, Becker RD, Jennis R, et al. MR imaging of brain abscesses. AJR Am J Roentgenol. 1989; 152:1073–1085.
Article
21. Hakan T, Ceran N, Erdem I, Berkman MZ, Göktaş P. Bacterial brain abscesses: an evaluation of 96 cases. J Infect. 2006; 52:359–366.
Article
22. Hirschberg H, Bosnes V. C-reactive protein levels in the differential diagnosis of brain abscesses. J Neurosurg. 1987; 67:358–360.
Article
23. Iannotti CA, Hall GS, Procop GW, Tuohy MJ, Staugaitis SM, Weil RJ. Solitary Nocardia farcinica brain abscess in an immunocompetent adult mimicking metastatic brain tumor: rapid diagnosis by pyrosequencing and successful treatment. Surg Neurol. 2009; 72:74–79. discussion 79.
Article
24. Jamjoom AB. Short course antimicrobial therapy in intracranial abscess. Acta Neurochir (Wien). 1996; 138:835–839.
Article
25. Kao PT, Tseng HK, Liu CP, Su SC, Lee CM. Brain abscess: clinical analysis of 53 cases. J Microbiol Immunol Infect. 2003; 36:129–136.
26. Lee TH, Chang WN, Su TM, Chang HW, Lui CC, Ho JT, et al. Clinical features and predictive factors of intraventricular rupture in patients who have bacterial brain abscesses. J Neurol Neurosurg Psychiatry. 2007; 78:303–309.
Article
27. Le Moal G, Landron C, Grollier G, Bataille B, Roblot F, Nassans P, et al. Characteristics of brain abscess with isolation of anaerobic bacteria. Scand J Infect Dis. 2003; 35:318–321.
Article
28. Lescop J, Brinquin L, Schill H, Soulié D, Sarrazin JL, Cordoliani YS. [Diffuse toxoplasmic encephalitis in a non-immunosuppressed patient.]. J Radiol. 1995; 76:21–24.
29. Longatti P, Perin A, Ettorre F, Fiorindi A, Baratto V. Endoscopic treatment of brain abscesses. Childs Nerv Syst. 2006; 22:1447–1450.
Article
30. Lu CH, Chang WN, Lui CC. Strategies for the management of bacterial brain abscess. J Clin Neurosci. 2006; 13:979–985.
Article
31. Lunsford LD. Stereotactic drainage of brain abscesses. J Neurosurg. 1989; 71:154.
Article
32. Mafee MF, Tran BH, Chapa AR. Imaging of rhinosinusitis and its complications: plain film, CT, and MRI. Clin Rev Allergy Immunol. 2006; 30:165–186.
Article
33. Mamelak AN, Mampalam TJ, Obana WG, Rosenblum ML. Improved management of multiple brain abscesses: a combined surgical and medical approach. Neurosurgery. 1995; 36:76–85. discussion 85-86.
Article
34. Mampalam TJ, Rosenblum ML. Trends in the management of bacterial brain abscesses: a review of 102 cases over 17 years. Neurosurgery. 1988; 23:451–458.
Article
35. Mandell BJ, Dolin R. Mandell, Douglas and Bennett's principles and practice of infectious disease. 6th ed. New York: Churchill Livingstone;2005. p. 2924–2931.
36. Mathisen GE, Johnson JP. Brain abscess. Clin Infect Dis. 1997; 25:763–779.
Article
37. Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, et al. Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis. DNA Res. 2008; 15:215–225.
Article
38. Ng PY, Seow WT, Ong PL. Brain abscesses: review of 30 cases treated with surgery. Aust N Z J Surg. 1995; 65:664–666.
Article
39. Nunez DA. Aetiological role of otolaryngological disease in paediatric intracranial abscess. J R Coll Surg Edinb. 1992; 37:80–82.
40. Nunez DA, Browning GG. Risks of developing an otogenic intracranial abscess. J Laryngol Otol. 1990; 104:468–472.
Article
41. Osenbach RK, Loftus CM. Diagnosis and management of brain abscess. Neurosurg Clin N Am. 1992; 3:403–420.
Article
42. Pit S, Jamal F, Cheah FK. Microbiology of cerebral abscess: a four-year study in Malaysia. J Trop Med Hyg. 1993; 96:191–196.
43. Quartey GR, Johnston JA, Rozdilsky B. Decadron in the treatment of cerebral abscess. An experimental study. J Neurosurg. 1976; 45:301–310.
44. Qureshi HU, Habib AA, Siddiqui AA, Mozaffar T, Sarwari AR. Predictors of mortality in brain abscess. J Pak Med Assoc. 2002; 52:111–116.
45. Roche M, Humphreys H, Smyth E, Phillips J, Cunney R, McNamara E, et al. A twelve-year review of central nervous system bacterial abscesses; presentation and aetiology. Clin Microbiol Infect. 2003; 9:803–809.
Article
46. Rosenblum ML, Mampalam TJ, Pons VG. Controversies in the management of brain abscesses. Clin Neurosurg. 1986; 33:603–632.
47. Salzman C, Tuazon CU. Value of the ring-enhancing sign in differentiating intracerebral hematomas and brain abscesses. Arch Intern Med. 1987; 147:951–952.
Article
48. Schroeder KA, McKeever PE, Schaberg DR, Hoff JT. Effect of dexamethasone on experimental brain abscess. J Neurosurg. 1987; 66:264–269.
Article
49. Seydoux C, Francioli P. Bacterial brain abscesses: factors influencing mortality and sequelae. Clin Infect Dis. 1992; 15:394–401.
Article
50. Sharma BS, Gupta SK, Khosla VK. Current concepts in the management of pyogenic brain abscess. Neurol India. 2000; 48:105–111.
51. Sharma BS, Khosla VK, Kak VK, Gupta VK, Tewari MK, Mathuriya SN, et al. Multiple pyogenic brain abscesses. Acta Neurochir (Wien). 1995; 133:36–43.
Article
52. Silva LA, Vieira RS, Serafini LN, Carlotti CG Jr, Figueiredo JF. [Toxoplasmosis of the central nervous system in a patient without immunosupression: case report.]. Rev Soc Bras Med Trop. 2001; 34:487–490.
53. Smego RA, Foglia G. Actinomycosis. Clin Infect Dis. 1998; 26:1255–1261.
Article
54. Smego RA Jr. Actinomycosis of the central nervous system. Rev Infect Dis. 1987; 9:855–865.
Article
55. Stephanov S, Joubert MJ. Large brain abscesses treated by aspiration alone. Surg Neurol. 1982; 17:338–340.
Article
56. Takeshita M, Kagawa M, Izawa M, Takakura K. Current treatment strategies and factors influencing outcome in patients with bacterial brain abscess. Acta Neurochir (Wien). 1998; 140:1263–1270.
Article
57. Tseng JH, Tseng MY. Brain abscess in 142 patients: factors influencing outcome and mortality. Surg Neurol. 2006; 65:557–562. discussion 562.
Article
58. Vander Top EA, Wyatt TA, Gentry-Nielsen MJ. Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae. Alcohol Clin Exp Res. 2005; 29:882–887.
Article
59. Wise BL, Gleason CA. CT-directed stereotactic surgery in the management of brain abscess. Ann Neurol. 1979; 6:457.
Article
60. Xiao F, Tseng MY, Teng LJ, Tseng HM, Tsai JC. Brain abscess: clinical experience and analysis of prognostic factors. Surg Neurol. 2005; 63:442–449. discussion 449-450.
Article
61. Yang SY. Brain abscess: a review of 400 cases. J Neurosurg. 1981; 55:794–799.
Article
Full Text Links
  • JKNTS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr