J Korean Neurosurg Soc.  2015 Jun;57(6):432-435. 10.3340/jkns.2015.57.6.432.

Quantitative Digital Subtraction Angiography in Pediatric Moyamoya Disease

Affiliations
  • 1Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea. cheonje@snu.ac.kr
  • 2Department of Radiology, Seoul National University Children's Hospital, Seoul, Korea.

Abstract

Moyamoya disease is a unique cerebrovascular disorder characterized by idiopathic progressive stenosis at the terminal portion of the internal carotid artery (ICA) and fine vascular network. The aim of this review is to present the clinical application of quantitative digital subtraction angiography (QDSA) in pediatric moyamoya disease. Using conventional angiographic data and postprocessing software, QDSA provides time-contrast intensity curves and then displays the peak time (Tmax) and area under the curve (AUC). These parameters of QDSA can be used as surrogate markers for the hemodynamic evaluation of disease severity and quantification of postoperative neovascularization in moyamoya disease.

Keyword

Moyamoya disease; Angiography; Digital subtraction

MeSH Terms

Angiography
Angiography, Digital Subtraction*
Biomarkers
Carotid Artery, Internal
Cerebrovascular Disorders
Constriction, Pathologic
Hemodynamics
Moyamoya Disease*
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