J Korean Neurol Assoc.
2014 May;32(2):98-102.
Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid Biomarkers for Alzheimer's Disease
- Affiliations
-
- 1Department of Neurology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sapark@schmc.ac.kr
- 2Department of Anesthesiology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
Abstract
- Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological, and radiologic data during 2 years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be similar to those found in Alzheimer's disease, with a decreased concentration of Abeta42 and an increased concentration of pTau181 (tTau).
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Early Onset Alzheimer's Disease Presenting as Logopenic Primary Progressive Aphasia
- Primary Progressive Aphasia and the Left Hemisphere Language Network
- Role of Positron Emission Tomography as a Biologic Marker in the Diagnosis of Primary Progressive Aphasia: Two Case Reports
- Cerebrospinal Fluid Aspartate Aminotransferase in Alzheimer Disease and Vascular Dementia
- Biological Predictors of Alzheimer's Disease Treatment
