J Korean Neurosurg Soc.  2011 Oct;50(4):322-326. 10.3340/jkns.2011.50.4.322.

Urgent Recanalization with Stenting for Severe Intracranial Atherosclerosis after Transient Ischemic Attack or Minor Stroke

• Park TS
• Choi BJ
• Lee TH
• Song JS
• Lee DY
• Sung SM

• KMID: 2190392
• DOI: http://doi.org/10.3340/jkns.2011.50.4.322

Abstract

OBJECTIVE
Stenting of symptomatic intracranial stenosis has recently become an alternative treatment modality. However, urgent intracranial stenting in patients with intracranial stenosis following a transient ischemic attack (TIA) or minor stroke is open to dispute. We sought to assess the feasibility, safety, and effectiveness of urgent intracranial stenting for severe stenosis (>70%) in TIA or minor stroke patients.
METHODS
Between June 2009 and October 2010, stent-assisted angioplasty by using a balloon-expandable coronary stent for intracranial severe stenosis (>70%) was performed in 7 patients after TIA and 5 patients after minor stroke (14 stenotic lesions). Technical success rates, complications, angiographic findings, and clinical outcomes were retrospectively analyzed.
RESULTS
Stenting was successful in all 12 patients. The mean time from symptom onset to stenting was 2.1 days (1-8 days). Post-procedural angiography showed restoration to a normal luminal diameter in all patients. In-stent thrombosis occurred in one patient (n=1, 8.3%), and was lysed with abciximab. No device-related complications, such as perforations or dissections at the target arteries or intracranial hemorrhaging, occurred in any patient. The mortality rate was 0%. No patient had an ischemic event over the mean follow-up period of 12.5 months (range, 7-21 months), and follow-up angiography (n=7) revealed no significant in-stent restenosis (>50%).
CONCLUSION
Urgent recanalization with stenting is feasible, safe, and effective in patients with TIA or acute minor stroke with intracranial stenosis of > or =70%.

Keyword

Acute ischemic stroke; Transient ischemic attack; Intracranial atherosclerosis; Intracranial stenting

MeSH Terms

Angiography
Angioplasty
Antibodies, Monoclonal
Arteries
Constriction, Pathologic
Dissent and Disputes
Follow-Up Studies
Humans
Immunoglobulin Fab Fragments
Intracranial Arteriosclerosis
Ischemic Attack, Transient
Phenobarbital
Retrospective Studies
Stents
Stroke
Thrombosis
Antibodies, Monoclonal
Immunoglobulin Fab Fragments
Phenobarbital