J Korean Soc Neonatol.  2003 May;10(1):61-66.

A Study on the Incidence and Risk factors of Cystic Periventricular Leukomalacia in very Low Birth Weight Infants

Affiliations
  • 1Department of Pediatrics, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea. wspark@smc.samsung.ac.kr
  • 2Department of Obstetrics and Gynecology, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.
  • 3Department of Pediatrics, Kangbuk Samsung Medical Center, Seoul, Korea.
  • 4Department of Pediatrics, Samsung Cheil Hospital, Seoul, Korea.

Abstract

PURPOSE
Our study was carried out to estimate the incidence of cystic periventricular leukomalacia (CPVL) and to identify the risk factors for CPVL. METHODS: The medical records and cranial ultrasound scan were reviewed for 321 infants weighing less than 1, 500 g who lived more than 28 days and admitted to the NICU at Samsung Medical Center from October 1995 to December 2001. A multiple logistic regression was performed to identify which factors were independently associated with CPVL. RESULT: CPVL developed in 19 (5.9%) infants of 1, 188+/-236 g birth weight and 28(+6)+/-2(+4) weeks gestational age. Incidence of CPVL according to birth weight and gestational age were as follows respectively: <750 g 5.3%, 750-999 g 5.5%, 1, 000-1, 249 g 3.9%, 1, 250-1, 499 g 7.9% and <25weeks 8.3%, 25-26weeks 6.7%, 27-28weeks 6.5%, 29-30weeks 2.7%, 31-32weeks 11.1%. The mean day of diagnosis of CPVL was 41+/-33 days. Univriate analysis indicate that two clinical variables, prolonged ventilator duration (CPVL: control, 35+/-64 days vs 17+/-26 days, P=0.0184) and severe intraventricular hemorrhage (IVH) (21% vs 2.7%, P=0.0324), were significant predictors of CPVL. The odds ratio estimate and 95% confidence limits are 1.012 and 1.003 to 1.022, respectively for prolonged ventilator duration; 2.6 and 1.044 to 6.602, respectively for severe IVH. CONCLUSIONS: These data suggest that prolonged ventilator duration and severe IVH increase the risk for development of CPVL.

Keyword

Cystic periventricular leukomalacia; Very low birth weight; Incidence; Risk factors

MeSH Terms

Birth Weight
Diagnosis
Gestational Age
Hemorrhage
Humans
Incidence*
Infant*
Infant, Newborn
Infant, Very Low Birth Weight*
Leukomalacia, Periventricular*
Logistic Models
Medical Records
Odds Ratio
Risk Factors*
Ultrasonography
Ventilators, Mechanical
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