J Korean Soc Neonatol.  2003 May;10(1):61-66.

A Study on the Incidence and Risk factors of Cystic Periventricular Leukomalacia in very Low Birth Weight Infants

• Lee SH
• Kim SH
• Lee KH
• You DK
• Choi SJ
• Hwang JH
• Choi CW
• Shim JW
• Ko SY
• Yang SH
• Chang YS
• Park WS

Abstract

PURPOSE
Our study was carried out to estimate the incidence of cystic periventricular leukomalacia (CPVL) and to identify the risk factors for CPVL. METHODS: The medical records and cranial ultrasound scan were reviewed for 321 infants weighing less than 1, 500 g who lived more than 28 days and admitted to the NICU at Samsung Medical Center from October 1995 to December 2001. A multiple logistic regression was performed to identify which factors were independently associated with CPVL. RESULT: CPVL developed in 19 (5.9%) infants of 1, 188+/-236 g birth weight and 28(+6)+/-2(+4) weeks gestational age. Incidence of CPVL according to birth weight and gestational age were as follows respectively: <750 g 5.3%, 750-999 g 5.5%, 1, 000-1, 249 g 3.9%, 1, 250-1, 499 g 7.9% and <25weeks 8.3%, 25-26weeks 6.7%, 27-28weeks 6.5%, 29-30weeks 2.7%, 31-32weeks 11.1%. The mean day of diagnosis of CPVL was 41+/-33 days. Univriate analysis indicate that two clinical variables, prolonged ventilator duration (CPVL: control, 35+/-64 days vs 17+/-26 days, P=0.0184) and severe intraventricular hemorrhage (IVH) (21% vs 2.7%, P=0.0324), were significant predictors of CPVL. The odds ratio estimate and 95% confidence limits are 1.012 and 1.003 to 1.022, respectively for prolonged ventilator duration; 2.6 and 1.044 to 6.602, respectively for severe IVH. CONCLUSIONS: These data suggest that prolonged ventilator duration and severe IVH increase the risk for development of CPVL.

Keyword

Cystic periventricular leukomalacia; Very low birth weight; Incidence; Risk factors

MeSH Terms

Birth Weight
Diagnosis
Gestational Age
Hemorrhage
Humans
Incidence*
Infant*
Infant, Newborn
Infant, Very Low Birth Weight*
Leukomalacia, Periventricular*
Logistic Models
Medical Records
Odds Ratio
Risk Factors*
Ultrasonography
Ventilators, Mechanical