Neonatal Med.  2014 Aug;21(3):172-178.

Risk Factors for Cystic Periventricular Leukomalacia in Very Low Birth Weight Infants

• Park JM
• Choi BS
• Sohn IA
• Seol IJ
• Kim CR
• Park HK
• Lee HJ

Abstract

PURPOSE
In the present study, we aimed to determine the risk factors for the development of cystic periventricular leukomalacia (CPVL) in very low birth weight (VLBW) infants.
METHODS
We reviewed the medical records of 309 infants weighing less than 1,500 g who were admitted to the neonatal intensive care unit at Hanyang University Medical Center, Seoul from April 2007 to December 2012. Thirty-nine infants died within 28 days of birth. Of the remaining 270 infants, 21 with CPVL established by cranial ultrasonography, and 63 without CPVL, who were matched for gestational age, were enrolled in this study. Univariate and multivariate analyses of maternal, perinatal, and neonatal risk factors for CPVL were performed through retrospective assessment of data collected from the medical records.
RESULTS
Necrotizing enterocolitis (NEC > or =stage II: 42.9% vs. 9.5%, P=0.002), culture-proven sepsis (66.7% vs. 34.9%, P=0.021), hypotension with sepsis (33.3% vs. 6.3%, P=0.004), and severe intraventricular hemorrhage (> or =grade III: 61.9% vs. 22.2%, P=0.002) were associated with the development of CPVL on univariate analysis. Using multivariate logistic regression analysis, two variables were found to be statistically significant independent risk factors: NEC (> or =stage II: adjusted OR, 5.12; 95% CI, 1.219-21.514; P=0.026) and hypotension with sepsis (adjusted OR, 8.23; 95% CI, 1.194-56.713; P=0.032).
CONCLUSION
NEC (> or =stage II) and hypotension with sepsis were associated with an increased risk of developing CPVL in VLBW infants.

Keyword

Cystic periventricular leukomalacia; Very low birth weight; Risk factors; Necrotizing enterocolitis; Hypotension; Sepsis

MeSH Terms

Academic Medical Centers
Enterocolitis, Necrotizing
Gestational Age
Hemorrhage
Humans
Hypotension
Infant*
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care, Neonatal
Leukomalacia, Periventricular*
Logistic Models
Medical Records
Multivariate Analysis
Parturition
Retrospective Studies
Risk Factors*
Seoul
Sepsis
Ultrasonography