J Korean Assoc Maxillofac Plast Reconstr Surg.  2009 Jan;31(1):61-66.

A case report; Brown tumor of the maxilla and mandible in association with primary hyperparathyroidism

• Lee JK
• Cho SD
• Leem DH

Abstract

The brown tumors develop in bone and it develop on various area which in clavicle, rib bone, cervical bone, iliac bone etc. The development on the maxillofacial region is rare, relatively more develop on the mandible. The brown tumor directly develop by the dysfunction of calcium metabolism according to hyperparathyroidism and differential diagnosis with other bone lesion should be difficult if it would diagnose by only radiographic features. The histological feature is that proliferation of spindle cells with extravasated blood and haphazardly arranged, variably sized, multinucleated giant cell is seen. The brown tumor is firm diagnosed by physical examination, because of these histological feature show similar with other giant cell lesions(giant cell granuloma, aneurysmal bone cyst, cherubism) The brown tumors have been described as resulting from an imbalance of osteoclastic and osteoblastic activity. It result in bone resorption and fibrous replacement of the bone. So these lesions represent the terminal stage of hyperparathyroidism-dependent bone pathology. Therefore, it is the extremely rare finding that brown tumor in the facial bone as the first manifestation of an hyperparathyroidism. We experience 1 case of brown tumor(50 years old female) that developed on Maxilla and mandible with no history of hyperparathyroidism. So we report this case with a literature review.

Keyword

Brown tumor; Primary hyperparathyroidism; Central giant cell lesion

MeSH Terms

Aneurysm
Bone Cysts
Bone Resorption
Calcium
Clavicle
Diagnosis, Differential
Facial Bones
Giant Cells
Granuloma
Hyperparathyroidism
Hyperparathyroidism, Primary
Mandible
Maxilla
Osteoblasts
Osteoclasts
Physical Examination
Ribs
Calcium