J Korean Med Assoc.  2007 Apr;50(4):316-323. 10.5124/jkma.2007.50.4.316.

Antiretroviral Therapy for Treatment of Human Immunodeficiency Virus Type 1 Infection

• Oh MD

• KMID: 2184848
• DOI: http://doi.org/10.5124/jkma.2007.50.4.316

Abstract

It has now been 20 years since the first demonstration that antiretroviral drug, azidothymidine, not only reduce human immunodeficiency virus type 1(HIV-1) replication but also improve clinical outcome. Antiretroviral therapy for treatment of HIV-1 infection has improved steadily since the introduction of combination therapy in 1996. With the advancement of antiretroviral therapy, the mortality of AIDS patients has markedly improved. Now, more than 20 anti-HIV drugs have been approved, providing more convenient dosing schedule and improved safety profiles. Despite these advances, suppression of HIV-1 replication would not sufficient to eradicate HIV-1 infection. This means that once antiretroviral therapy is initiated, patients can expect to be taking it for the rest of their lives. And long-term drug toxicities, development of drug resistant HIV-1, treatment cost have been emerging as new challenges for the treatment of HIV-1 infection. As the life expectancy of HIV-1 patients have been increased, chronic illnesses such as cardiovascular diseases, chronic liver diseases, and malignancies have emerged as major cause of mortality and morbidities of HIV-1 patients. Therefore, comprehensive care and team approaches have becoming increasingly important for the care of HIV-1 patients.

Keyword

HIV-1 infection; Antiretroviral therapy; Antiretroviral drugs

MeSH Terms

Anti-HIV Agents
Appointments and Schedules
Cardiovascular Diseases
Chronic Disease
Drug-Related Side Effects and Adverse Reactions
Health Care Costs
HIV*
HIV-1*
Humans*
Life Expectancy
Liver Diseases
Mortality
Zidovudine
Anti-HIV Agents
Zidovudine

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