J Korean Bal Soc.  2008 Jun;7(1):73-76.

A Case of Apogeotropic Positional Nystagmus Associated With Anti-GD1b IgG Antibody

  • 1Department of Neurology, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. mseaj@eulji.ac.kr
  • 2Department of Neurology, Chungbuk National University, College of Medicine, Chungbuk National University Hospital, Korea.
  • 3Department of Neurology, Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Korea.


The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.


Anti-GD1b IgG antibody; Apogeotropic nystagmus; Positron emission tomography
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