J Korean Foot Ankle Soc.  2013 Sep;17(3):203-208.

Pyridoxine in the Treatment of Peripheral Nerve Related Foot Pain

Affiliations
  • 1Department of Orthopedic Surgery, Sanggye Paik Hospital, Inje University, Seoul, Korea. youngos@paik.ac.kr
  • 2The 3rd Artillery Brigade, 5882 Unit, Republic of Korea.

Abstract

PURPOSE
We analyzed retrospectively the effect of pyridoxine in the treatment of peripheral nerve related foot pain because we have seen favorable clinical results from it as a monotherapy.
MATERIALS AND METHODS
We analyzed the clinical results of 200 cases of peripheral nerve related foot pain, treated with pyridoxine from March 2009 to February 2012. We devided them into three groups, peripheral neuritis, Morton's neuroma and posttraumatic neuralgia and recorded percentage of improvement of pain, compared to initial pain level at 2 weeks and 6 weeks.
RESULTS
There were 127 peripheral neuritis cases, 22 Morton's neuroma and 51 posttraumatic neuralgia. At 2 weeks after treatment, 135 cases(67.5%) showed pain relief. At 6 weeks, 36 cases(21%) showed complete improvement of pain, 81 cases(47%) showed more than 50% of improvement, 22 cases(13%) showed less than 50% of improvement and 33 cases(19%) showed no improvement. There are 4 cases of gastrointestinal discomfort and 2 cases of aggravation of nervy pain.
CONCLUSION
Pyridoxine was effective drug in the treatment of peripheral neuropathic pain in terms of pain relief, safety and cost effectiveness. So it can be an available first line drug before adding other drugs.

Keyword

Foot; Neuropathic pain; Medication; Pyridoxine

MeSH Terms

Cost-Benefit Analysis
Foot
Neuralgia
Neuritis
Neuroma
Peripheral Nerves
Pyridoxine
Retrospective Studies
Pyridoxine
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