J Asthma Allergy Clin Immunol.  2003 Dec;23(4):826-832.

A case of eosinophilic cellulitis associated with angioedema and eosinophilia

Affiliations
  • 1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dcchoi@smc.samsung.co.kr

Abstract

Eosinophilic cellulitis was first described by Wells, which is characterized by cellulitis like skin lesion, eosinophilic infiltration of dermis and subcutaneous fat with characteristic flame figure appearance of chollagen bundles. Peripheral eosinophilia is not necessary for the diagnosis of eosinophilic cellulitis, but association with hypereosinophilic syndrome was reported. Episodic angioedema associated with eosinophilia was first described by Gleich et al. as recurrent attack of angioedema; peripheral eosinophilia; and body weight gain; they described this as separate disease entity rather than variant of the hypereosinophilic syndrome. Both angioedema associated with eosinophilia and eosinophilic cellulitis were reportedly associated with hypereosinophilic syndrome, and we believe both diseases are variants of idiopathic hypereosinophilic syndrome. We experienced a patient with eosinophilic cellulitis who has expressed skin lesion resembling angioedema associated with eosinophilia, and who also has involvement of pleura and gastrointestinal tract. We speculate that this patient represents an overlap syndrome of idiopathic hypereosinophilic syndrome, eosinophilic cellulitis and angioedema associated with eosinophilia.

Keyword

Eosinophilia; hypereosinophilic syndrome; angioedema; cellulitis

MeSH Terms

Angioedema*
Body Weight
Cellulitis*
Dermis
Diagnosis
Eosinophilia*
Eosinophils*
Gastrointestinal Tract
Humans
Hypereosinophilic Syndrome
Pleura
Skin
Subcutaneous Fat
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