J Korean Med Sci.  2001 Oct;16(5):664-668. 10.3346/jkms.2001.16.5.664.

Eosinophilic Cellulitis (Wells' Syndrome) Successfully Treated With Low-dose Cyclosporine

  • 1Department of Dermatology, Asan-Foundation Kangnung Hospital, Kangnung, University of Ulsan College of Medicine, Seoul, Korea.


Eosinophilic cellulitis (Wells'syndrome) is an uncommon skin disorder. We report two adult male patients who had recurrent erythematous plaques and a nodular lesion on the abdomen. The histopathologic feature of their skin biopsies similarly indicated a marked infiltrate of eosinophils in the dermis with the fashion of "flame figures". One of the patients demonstrated blood eosinophilia. Given the clinicohistological findings, the patients fulfilled the criteria for the diagnosis of eosinophilic cellulitis. The skin lesions remained refractory to medications such as corticosteroids, sulfones, antihistamines, and minocycline. Considering the beneficial effect of cyclosporine in the treatment of eosinophilia-associated dermatoses, we speculated that eosinophilic cellulitis might respond to cyclosporine therapy. Thus, each of the two patients was given cyclosporine (microemulsion formulation) at a daily dose of 1.25 or 2.5 mg/kg, i.e., 100 or 200 mg, respectively. Complete remission of the skin eruptions was obtained in both patients during a 3- or 4-week period of treatment. No side effects were observed. Neither of the patients experienced relapse of the disease at least over 10 months after the discontinuation of the cyclosporine therapy. We suggest that administration of low-dose cyclosporine be a safe and useful therapeutic option in patients with eosinophilic cellulitis.


Cellulitis; Eosinophilic Cellulitis (Well's Syndrome); Cyclosporine

MeSH Terms

Case Report
Cellulitis/*drug therapy
Cyclosporine/*therapeutic use
Eosinophilia/*drug therapy
Immunosuppressive Agents/*therapeutic use

Cited by  1 articles

Bullous Eosinophilic Cellulitis (Wells' Syndrome) in a Patient with Churg-Strauss Syndrome: A Case Report and Review of Literatures
Kyung-Chan Kim, Hyun Chung, Joon Soo Park, Jae Bok Park, Jung-Yoon Choe, Sung-Hoon Park, Ji-Young Kim, Seong-Kyu Kim
J Korean Rheum Assoc. 2008;15(1):48-53.    doi: 10.4078/jkra.2008.15.1.48.

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