J Gynecol Oncol.  2012 Apr;23(2):129-132. 10.3802/jgo.2012.23.2.129.

Successful pregnancy following transfer of frozen-thawed embryos in a patient with pseudomyxoma peritonei who underwent peritonectomy and bilateral oophorectomy

• Laskov I
• Michaan N
• Many A
• Amit A
• Azem F

• KMID: 2177588
• DOI: http://doi.org/10.3802/jgo.2012.23.2.129

Abstract

Pseudomyxoma peritonei is a rare, chronic relapsing disease in which tumor cells in the abdomen produce excessive mucin with a significant mortality rate. We describe a young unmarried nulligrava who underwent fertility preservation by in vitro fertilisation and embryo cryopreservation prior to radical surgery and adjuvant chemotherapy. Pregnancy was achieved, although complicated by obstructive uropathy. She delivered a healthy infant at 32 weeks' gestation. The few descriptions of fertility and pregnancy outcome in pseudomyxoma peritonei that appear in the literature are reviewed.

Keyword

Embryo cryopreservation; Fertility preservation; Pregnancy; Pseudomyxoma peritonei

MeSH Terms

Abdomen
Chemotherapy, Adjuvant
Cryopreservation
Embryonic Structures
Female
Fertility
Fertility Preservation
Humans
Infant
Mucins
Ovariectomy
Pregnancy
Pregnancy Outcome
Pseudomyxoma Peritonei
Single Person
Mucins

Figure

• 

  Fig. 1 Disseminated peritoneal adenomucinosis: peritoneal lesion showed simple mucinous epithelial strips with abundant extracellular mucin. Epithelium had no cytologic atypia or mitosis (H&E, ×20).

Reference

1. Manan AZ, Raja MH, Namukangula R, Benayan AA. Appendiceal pseudomyxoma peritonei in a pregnant woman. Saudi Med J. 2010. 31:572–574.

2. Koyama S, Tomimatsu T, Sawada K, Kanagawa T, Tsutsui T, Kimura T. Pseudomyxoma peritonei originating from colorectal cancer during pregnancy. J Obstet Gynaecol Res. 2011. 37:254–258.

3. Ikenaga M, Mishima H, Miyazaki M, Kashiwazaki M, Hirao M, Fujitani K, et al. A case of pseudomyxoma peritonei arising from mucinous cystadenoma of the appendix during pregnancy. J Jpn Coll Surg. 2006. 31:91–95.

4. Niwa K, Morishita S, Murase T, Kawabata I, Imai A, Shimokawa K, et al. Successful pregnancy in a patient with pseudomyxoma peritonei arising from ovarian mucinous cystadenocarcinoma treated with cisplatin. Gynecol Oncol. 1995. 59:398–400.

5. Hales HA, Peterson CM, Jolles CJ, Varner MW, Keye WR. Pseudomyxoma peritonei associated with secondary infertility. Fertil Steril. 1992. 58:425–426.

6. Narvekar S, Vijaykumar P, Shetty N, Srinivas M, Rao K. Successful pregnancy in a patient with pseudomyxoma peritonei following in-vitro fertilization using donor eggs. J Hum Reprod Sci. 2008. 1:90–92.

7. Qu ZB, Liu LX. Management of pseudomyxoma peritonei. World J Gastroenterol. 2006. 12:6124–6127.

8. Jivan S, Bahal V. Pseudomyxoma peritonei. Postgrad Med J. 2002. 78:170–172.

9. Esquivel J, Sugarbaker PH. Clinical presentation of the Pseudomyxoma peritonei syndrome. Br J Surg. 2000. 87:1414–1418.

10. Bevan KE, Mohamed F, Moran BJ. Pseudomyxoma peritonei. World J Gastrointest Oncol. 2010. 2:44–50.