Blood Res.  2014 Mar;49(1):66-69. 10.5045/br.2014.49.1.66.

A rare case of isolated myeloid sarcoma of the small gut with inv(16)(p13;q22) without bone marrow involvement

• Mandal PK
• Dolai TK

• KMID: 2172827
• DOI: http://doi.org/10.5045/br.2014.49.1.66

Abstract

No abstract available.

MeSH Terms

Bone Marrow*
Sarcoma, Myeloid*

Figure

• 

  Fig. 1 Contrast enhanced computerized tomography of the abdomen, showing a soft tissue mass lesion (arrow) in the left side of the mesentery with adherent small gut loops.

• 

  Fig. 2 Section from the small intestine showing a dense infiltrate of myeloid precursor cells (Hematoxylene and Eosin stain, 40× magnification).

• 

  Fig. 3 Biopsy specimen showing a tumor composed of sheets of myeloid precursor cells with moderate cytoplasm, a high nucleocytoplasmic ratio, and occasional prominent nucleoli. A fair number of eosinophils were seen (arrow). (Hematoxylene and Eosin stain, 100× magnification; inset-400×).

Reference

1. Pilieri SA, Orazi A, Falini B. Myeloid sarcoma. In : Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press;2008. p. 140–141.

2. Audouin J, Comperat E, Le Tourneau A, et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 2003; 11:271–282. PMID: 14615822.

3. Menasce LP, Banerjee SS, Beckett E, Harris M. Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. Histopathology. 1999; 34:391–398. PMID: 10231412.

4. Maeng H, Cheong JW, Lee ST, et al. Isolated extramedullary relapse of acute myelogenous leukemia as a uterine granulocytic sarcoma in an allogeneic hematopoietic stem cell transplantation recipient. Yonsei Med J. 2004; 45:330–333. PMID: 15119007.

5. Eshghabadi M, Shojania AM, Carr I. Isolated granulocytic sarcoma: report of a case and review of the literature. J Clin Oncol. 1986; 4:912–917. PMID: 2423654.

6. Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood. 2011; 118:3785–3793. PMID: 21795742.

7. Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995; 13:1800–1816. PMID: 7602369.

8. Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma. 2006; 47:2527–2541. PMID: 17169797.

9. Choi EK, Ha HK, Park SH, et al. Granulocytic sarcoma of bowel: CT findings. Radiology. 2007; 243:752–759. PMID: 17446522.

10. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007; 21:340–350. PMID: 17170724.

11. Kumar B, Bommana V, Irani F, Kasmani R, Mian A, Mahajan K. An uncommon cause of small bowel obstruction: isolated primary granulocytic sarcoma. QJM. 2009; 102:491–493. PMID: 19433489.

12. Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer. 1986; 58:2697–2709. PMID: 3465429.

13. Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer. 2002; 94:1739–1746. PMID: 11920536.

14. Hayashi T, Kimura M, Satoh S, et al. Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma. Leukemia. 1998; 12:1501–1503. PMID: 9737707.

15. Kohl SK, Aoun P. Granulocytic sarcoma of the small intestine. Arch Pathol Lab Med. 2006; 130:1570–1574. PMID: 17090205.