Blood Res.  2015 Jun;50(2):67-68. 10.5045/br.2015.50.2.67.

Mesenchymal niche: the sensor and effector of leukemogenesis

• Oh IH

• KMID: 2172766
• DOI: http://doi.org/10.5045/br.2015.50.2.67

Abstract

No abstract available.

Reference

1. Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011; 9:11–15. PMID: 21726829.

2. Sacchetti B, Funari A, Michienzi S, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007; 131:324–336. PMID: 17956733.

3. Oh IH, Kwon KR. Concise review: multiple niches for hematopoietic stem cell regulations. Stem Cells. 2010; 28:1243–1249. PMID: 20517982.

4. Ishikawa F, Yoshida S, Saito Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 2007; 25:1315–1321. PMID: 17952057.

5. Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science. 2008; 322:1861–1865. PMID: 19095944.

6. Zhang B, Ho YW, Huang Q, et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell. 2012; 21:577–592. PMID: 22516264.

7. Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM. Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood. 2012; 119:540–550. PMID: 21957195.

8. Walkley CR, Olsen GH, Dworkin S, et al. A microenvironmentinduced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007; 129:1097–1110. PMID: 17574023.

9. Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007; 129:1081–1095. PMID: 17574022.

10. Kim JA, Shim JS, Lee GY, et al. Microenvironmental remodeling as a parameter and prognostic factor of heterogeneous leukemogenesis in acute myelogenous leukemia. Cancer Res. 2015; 75:2222–2231. PMID: 25791383.