The Insulin Response and Clinical Features According to the Patterns of Glucose Tolerance.

Kim, Yong Joo; Kim, Jung MIn; Kim, Myung Soo; Kim, Ji Youn; Lee, Dae Bae; Sin, Hyun Ho; Cho, Dong Hyuk; Lee, Youn Sang; Yang, Seung Won; Chung, Kong Jin; Chung, Min Young; Lee, Tai Hee

Abstract

Even subjects with normal fasting glucose may show glucose intolerance. Insulin response after oral glucose administration is known to be influenced by race, body mass index, fasting insulin level, and age, but in Koreans there reportedly is some differences about it. 3-hour 75 gram oral glucose tolerance tests were performed in 162 healthy adults (79 male and 83 female: aged 49.7+/-1.41 years) with fasting glucose 5.6+/-~6.7mmol/L(100-119mg/dL). We classified each of them for the glucose tolerance, and tried to find out the relationship with the clinical characteristics. There were no significant differences in the age, BMI, HbA1c, blood pressure, diabetic family history, and sex among the there groups. The level of the fasting blood glucose and postload blood glucose were significantly higher in group with diabetes mellitus. Insulin response to an oral glucose administration at 30min was significantly increased in group with normal glucose tolerance as compared to group of diabetes mellitus. The early insulin responses were all inversely related to the severity of glucose intolerance, but late insulin responses were correlated to severity of the glucose intolerance. The peak insulin response to an oral glucose load was significantly delayed in glucose with diabetes mellitus and impaired glucose tolerance. In the insulin response area which could be indicator of insulin response, the three groups had no significant differences among themselves, but showed close relationship with basal insulin response in normal glucose tolerance, and with HbA1c, basal insulin response in impaired glucose tolerance, and triglyceride in diabetes mellitus. Glucose tolerance and amount of insulin secretion showed variable features among those subjects with normal fasting blood glucose. Although there were no significant differences in clinical characteristics, insulin secretory response was correlated well with fasting insulin level. HbA1c, and serum triglyceride level in according to glucose tolerance.