J Korean Soc Endocrinol.  1994 Mar;9(1):54-58.

Evaluation of Glucone Tolerance and Insulin Secretion in Two Patients with Primary Hyperparathyroidism Before and After Surgery

• Ihm SH
• Choi MG
• Yoo HJ
• Chun SH
• Choi YS
• Lee GY
• Lim IS
• Park SW

Abstract

It is reported that patients with primary hyperparathyroidism(PHPT) have disturbances in carbohydrate metabolism: in particular, hyperinsulinemia and insulin resistance are characteristic early metabolic aberrations of this disease. However, it is not clear whether changes of insulin secretion or insulin sensitivity are observed in all patients with PHPT, including those with normal glucose tolerance. Also, it is not clear whether these changes are reversible after surgical correction of PHPT. In the present study, glucose tolerance and insulin secretion were evaluated in 2 symptomatic patients with PHPT during 100g oral glucose tolerance test before and after parathyroid adenoma removal. Comparing these patients before and after surgery, glucose tolerance was not significantly different. However, C-peptide and insulin secretion was low after surgical correction of PHPT compared to the preoperative situation. This observation suggests that insulin hypersecretion in patients with PHPT precedes glucose intolerance and this early disturbance is reversible after surgery.

MeSH Terms

C-Peptide
Carbohydrate Metabolism
Glucose
Glucose Intolerance
Glucose Tolerance Test
Humans
Hyperinsulinism
Hyperparathyroidism, Primary*
Insulin Resistance
Insulin*
Parathyroid Neoplasms
C-Peptide
Glucose
Insulin