Ann Dermatol.  2010 Feb;22(1):114-118. 10.5021/ad.2010.22.1.114.

Identification of Cutaneous Mycobacterium massiliense Infections Associated with Repeated Surgical Procedures

• Cho AY
• Kim YS
• Kook YH
• Kim SO
• Back SJ
• Seo YJ
• Lee JH
• Lee Y

• KMID: 2172055
• DOI: http://doi.org/10.5021/ad.2010.22.1.114

Abstract

Mycobacterium massiliense, an emerging pathogen that is increasingly reported as a causative agent in infections occurring during medical procedures, is difficult to be identified using conventional methods. Here we report the case of a cutaneous M. massiliense infection that was associated with repeated surgical procedures and that was identified via a comparative sequence analysis of rpoB and hsp65. The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin, amikacin, and cefoxitin for 6 months.

Keyword

Mycobacterium massiliense

MeSH Terms

Amikacin
Cefoxitin
Clarithromycin
Humans
Mycobacterium
Sequence Analysis
Amikacin
Cefoxitin
Clarithromycin

Figure

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  Fig. 1 A tender, erythematous-to-brownish plaque located on the left thigh.

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  Fig. 2 Histopathological findings of the lesion showed epithelial hyperplasia and a neutrophilic abscess with granulomatous inflammation in the dermis (H&E, A: ×40; B: ×100).

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  Fig. 3 (A) Small white colonies were observed on the Sabouraud agar plate after 4 weeks of culture. (B) Ivory-coloured, smooth colonies with elevated centers were observed on the blood agar plate after 5 days of culture.

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