Ann Dermatol.  2011 Feb;23(1):95-97. 10.5021/ad.2011.23.1.95.

Unilateral Nevoid Acanthosis Nigricans with a Submammary Location

• Jeong JS
• Lee JY
• Yoon TY

• KMID: 2171963
• DOI: http://doi.org/10.5021/ad.2011.23.1.95

Abstract

Unilateral nevoid acanthosis nigricans (AN) is an exceedingly rare form of AN, which is a benign disorder of keratinization. The lesions of unilateral nevoid AN are distributed unilaterally while the histopathologic findings are similar to the common form of AN, and this is characterized by hyperkeratosis, papillomatosis and moderate acanthosis. A 19-year-old female presented with asymptomatic brownish pigmented plaques on the medial side of the left submammary area. Based on her clinical and histopathologic findings, a diagnosis of unilateral nevoid AN was made. She was treated with topical tretinoin and her skin lesions were almost cleared 9 months after her first visit to our clinic. Various previous reports have described the localization of this disorder, but there has been no previous case report with the clinical manifestations on the unilateral submammary area. Therefore, we herein report the first case of unilateral nevoid AN with an unusual submammary location.

Keyword

Acanthosis nigricans; Submammary; Unilateral

MeSH Terms

Acanthosis Nigricans
Female
Humans
Keratins
Papilloma
Skin
Tretinoin
Young Adult
Keratins
Tretinoin

Figure

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  Fig. 1 (A) Linear verrucous brownish plaques on the intermammary to left submammary area and (B) substantial clearance 9 months after the initiation of topical tretinoin treatment.

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  Fig. 2 (A) Hyperkeratosis, papillomatosis and moderate acanthosis are seen in the epidermis (H&E, ×100). All the immunoreactivities for estrogen receptor (B), progesterone receptor (C) and androgen receptor (D) are negative in the epidermis (immunoperoxidase, ×400). (B) Inset: immunohistochemistry for estrogen receptor in the ductal carcinoma cells of the breast as the positive control (immunoperoxidase, ×400).

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