Clin Psychopharmacol Neurosci.  2015 Dec;13(3):269-274. 10.9758/cpn.2015.13.3.269.

The Changes of Psychometric Profiles after Medical Treatment of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia

• Cho KJ
• Lee NS
• Lee YS
• Jeong WJ
• Suh HJ
• Kim JC
• Koh JS

• KMID: 2171028
• DOI: http://doi.org/10.9758/cpn.2015.13.3.269

Abstract

OBJECTIVE
To investigate the relationship of somatization and depression with the degree of lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and changes in psychometric profiles including somatization and depression after treatment of LUTS/BPH.
METHODS
Subjects were evaluated at baseline and at week 12 following routine treatment for LUTS/BPH using the International Prostate Symptom Score (IPSS) to measure the severity of LUTS/BPH, the Overactive Bladder Symptom Score (OABSS) to measure the severity of OAB, the Patient Health Questionnaire-9 (PHQ-9) to assess depression, and the Patient Health Questionnaire-15 (PHQ-15) to evaluate somatization. The correlation of somatization and depression with the degree of LUTS/BPH symptoms at baseline and changes in somatization and depression after LUTS/BPH treatment were assessed using relevant statistical analyses.
RESULTS
One hundred and twenty patients agreed to participate in this study, and 101 (84.2%) completed the 12-week trial and responded to the study questionnaires. At baseline, total IPSS score was correlated with PHQ-9 (r=0.475, p=0.005) and PHQ-15 (r=0.596, p<0.001) scores. The results after the 12-week treatment clearly show significant improvement in both PHQ-9 (p <0.001) and PHQ-15 (p=0.019) scores, and the PHQ-9 (r=0.509, p=0.048) and PHQ-15 (r=0.541, p=0.016) scores were positively correlated with total IPSS.
CONCLUSION
Our preliminary results indicated that severity of LUTS is correlated with severity of somatization and depression. Further, the improvement of LUTS after treatment may have positive impacts on somatization and depression.

Keyword

Prostatic hyperplasia; Depression; Lower urinary tract symptoms; Somatization disorders; Treatment outcome

MeSH Terms

Depression
Humans
Hyperplasia
Lower Urinary Tract Symptoms*
Prostate
Prostatic Hyperplasia*
Psychometrics*
Somatoform Disorders
Treatment Outcome
Urinary Bladder, Overactive