Infect Chemother.  2014 Dec;46(4):248-252. 10.3947/ic.2014.46.4.248.

Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis

• Lee YM
• Kim SM
• Park SJ
• Lee SO
• Choi SH
• Kim YS
• Woo JH
• Kim SH

• KMID: 2170493
• DOI: http://doi.org/10.3947/ic.2014.46.4.248

Abstract

Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as > or =1,000 spot-forming units (SFU)/2.5x10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (< or = 99 SFU (6-99 SFU)/2.5x10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

Keyword

Interferon-gamma release assay; Tuberculosis; Miliary

MeSH Terms

Humans
Immunosuppression
Interferon-gamma Release Tests
Tuberculosis*

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