Infect Chemother.  2014 Dec;46(4):248-252. 10.3947/ic.2014.46.4.248.

Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis

Affiliations
  • 1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kimsunghanmd@hotmail.com
  • 2Department of Infectious Diseases, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract

Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as > or =1,000 spot-forming units (SFU)/2.5x10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (< or = 99 SFU (6-99 SFU)/2.5x10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

Keyword

Interferon-gamma release assay; Tuberculosis; Miliary

MeSH Terms

Humans
Immunosuppression
Interferon-gamma Release Tests
Tuberculosis*

Cited by  1 articles

Association between Body Mass Index and Sputum Culture Conversion among South Korean Patients with Multidrug Resistant Tuberculosis in a Tuberculosis Referral Hospital
Hyun-Oh Park, Sung-Hwan Kim, Seong-Ho Moon, Joung-Hun Byun, Jong-Woo Kim, Chung-Eun Lee, Jong-Duk Kim, In-Seok Jang, Jun-Ho Yang
Infect Chemother. 2016;48(4):317-323.    doi: 10.3947/ic.2016.48.4.317.


Reference

1. Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K. IGRA Expert Committee. Centers for Disease Control and Prevention (CDC). Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection - United States, 2010. MMWR Recomm Rep. 2010; 59:1–25.
2. Chee CB, Barkham TM, Khinmar KW, Gan SH, Wang YT. Quantitative T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens in active and latent tuberculosis. Eur J Clin Microbiol Infect Dis. 2009; 28:667–670.
Article
3. Kobashi Y, Mouri K, Yagi S, Obase Y, Miyashita N, Oka M. Transitional changes in T-cell responses to Mycobacterium tuberculosis-specific antigens during treatment. J Infect. 2009; 58:197–204.
Article
4. Metcalfe JZ, Cattamanchi A, Vittinghoff E, Ho C, Grinsdale J, Hopewell PC, Kawamura LM, Nahid P. Evaluation of quantitative IFN-gamma response for risk stratification of active tuberculosis suspects. Am J Respir Crit Care Med. 2010; 181:87–93.
Article
5. Kim SH, Choi SJ, Kim HB, Kim NJ, Oh MD, Choe KW. Diagnostic usefulness of a T-cell based assay for extrapulmonary tuberculosis. Arch Intern Med. 2007; 167:2255–2259.
Article
6. Kim SH, Song KH, Choi SJ, Kim HB, Kim NJ, Oh MD, Choe KW. Diagnostic usefulness of a T-cell-based assay for extrapulmonary tuberculosis in immunocompromised patients. Am J Med. 2009; 122:189–195.
Article
7. Kim SH, Cho OH, Park SJ, Lee EM, Kim MN, Lee SO, Choi SH, Kim YS, Woo JH, Lee SA, Kang JK. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin Infect Dis. 2010; 50:1349–1358.
Article
8. Sharma SK, Mohan A, Sharma A, Mitra DK. Miliary tuberculosis: new insights into an old disease. Lancet Infect Dis. 2005; 5:415–430.
Article
9. Lee YM, Park KH, Kim SM, Park SJ, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH. Diagnostic usefulness of a T-cell-based assay in patients with miliary tuberculosis compared with those with lymph node tuberculosis. Clin Infect Dis. 2013; 56:e26–e29.
Article
10. Chee CB, KhinMar KW, Gan SH, Barkham TM, Koh CK, Shen L, Wang YT. Tuberculosis treatment effect on T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens. Eur Respir J. 2010; 36:355–361.
Article
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